Abstract 14345: Kaolin-containing Hemostatic Gauze Reduced The Re- bleeding Rate Following Catheter Ablation for Atrial Fibrillation
Introduction: Hemostatic gauze containing kaolin, which promotes clotting cascade, has been used for hemostasis during surgery. However, efficacy of kaolin-containing hemostatic gauze (KG) in patients undergoing atrial fibrillation (AF) ablation is unknown.
Hypothesis: Use of KG reduces the re-bleeding rate following catheter ablation for AF.
Methods: In this observational study, 425 patients who underwent catheter ablation for AF were included. After the femoral sheath was extracted, blood access site was manually compressed using KG (QuickClot™ Interventional, KG group) or normal gauze (normal gauze group) until hemostasis was achieved. Optimal oral anticoagulation therapy was continued throughout the periprocedural period. Re-bleeding events were defined as re-bleeding necessitating additional hemostatic procedure after leaving the electrophysiological laboratory.
Results: KG group comprised 235 patients (55.3%). There were no difference in age (68.1±9.2 vs. 66.5±9.0 years old, P = 0.073), gender (male; 66.3% vs. 67.2%, P = 0.84), CHADS2 score (1.3±1.1 vs. 1.2±0.9, P = 0.28), antiplatelet agents usage (13.1% vs. 10.6%, P = 0.42) between the groups. Re-bleeding rate was significantly lower in KG group than in normal gauze group (6.0% vs. 11.5%, P = 0.039). Notably, the efficacy of KG was more prominent in the reduction of re-bleeding events after the removal of gauze compression (0.4 % vs. 5.7%, P <0.001). Independent negative predictors of re-bleeding were the use of KG (odds ratio (OR) = 0.49 [95% confidence interval (CI) 0.241-0.998], P =0.049) and high body mass index (OR= 0.87 [95%CI 0.777-0.972], P =0.014).
Conclusions: Kaolin-containing hemostatic gauze was effective for the reduction of re-bleeding events following catheter ablation for AF via the femoral access.
Author Disclosures: Y. Matsuda: None. M. Masuda: None. M. Fujita: None. O. Iida: None. S. Okamoto: None. T. Ishihara: None. K. Nanto: None. T. Kanda: None. A. Sunaga: None. T. Tsujimura: None. S. Okuno: None. K. Yanaka: None. T. Ohashi: None. H. Kawai: None. A. Tsuji: None. Y. Hata: None. M. Uematsu: None.
- © 2016 by American Heart Association, Inc.