Abstract 14225: The Impact of Family History of Premature Cerebrocardiovascular Disease or Diabetes Mellitus on the Occurrence of Gestational Hypertensive Disease and Diabetes
Introduction: Gestational hypertensive diseases (GHD) and gestational diabetes mellitus (GDM) are well-known to increase the risk of cerebrocardiovascular diseases (CCVD) later in life. However, the association between gestational diseases and the familial history of CCVD has not been investigated yet.
Hypothesis: Family history of CCVD may be a predictor of GHD or GDM.
Methods: The Korean Nurses’ Survey was conducted through web-based computer-assisted self-interview, which was compiled by consultation to cardiologists, gynecologists, and statisticians. We enrolled a total of 9,989 female registered nurses who could answer reliably the questionnaires including the family history of premature CCVD (FHCVD), hypertension (FHH), diabetes mellitus (FHDM) based on their medical knowledge. Either multivariate logistic regression analysis or generalized estimation equation was used to clarify the effect of the family histories on GHD and GDM in individual subjects or at each repeated pregnancy in an individual.
Results: In this survey, 3,695 subjects had more than 1 pregnancy and 8,783 accumulative pregnancies. Among them, 247 interviewees (6.3%) experienced GHD and 120 (3.1%) experienced GDM. In a multivariate analysis adjusting the family histories, obstetric and gynecologic variables, the age at the first pregnancy more than 35 years (adjusted OR 1.61, 95% CI 1.02 - 2.43, p = 0.030) and FHCVD (adjusted OR 1.60, 95% CI 1.16 - 2.22, p = 0.004) were significant factors for GHD in individuals whereas FHH was not. FHDM and a history of infertility therapy were significant risk factors for GDM in individuals (adjusted OR 2.68, 95% CI 1.86 - 3.86, p < 0.001; 1.66, 95% CI 1.02 - 2.85, p = 0.079). In any repeated pregnancies in an individual, age at the pregnancy, the first pregnancy and FHCVD were significant risk factors for GHD while age at the pregnancy, history of infertility therapy and FHDM were significant risk factors for GDM.
Conclusions: The FHCVD or FHDM is significantly associated with GHD or GDM, respectively. Meticulous family history should be taken and then special monitoring should be performed for the women with the family histories during pregnancy.
Author Disclosures: C. Yoon: None. I. Chae: None. D. Choi: None.
- © 2016 by American Heart Association, Inc.