Abstract 14217: A Significant Correlation Between Nitroglycerine-induced Vasodilation in Coronary and Brachial Arteries
Introduction: Nitroglycerine-induced vasodilation, an index of endothelium-independent vasodilation, is measured for the assessment of vascular smooth muscle cell function or alterations of vascular structure as a control for endothelial function test. Both coronary and brachial artery responses to nitroglycerine have been reported to be independent prognostic markers of cardiovascular events. The purpose of this study was to compare the nitroglycerine-induced vasodilation in the coronary and brachial arteries in the same patients.
Hypothesis: There is a significant correlation between nitroglycerine-induced vasodilation in coronary and brachial arteries.
Methods: We measured nitroglycerine-induced vasodilation in coronary and brachial arteries in 30 subjects who underwent coronary angiography with suspected coronary artery disease (19 men and 11 women; mean age, 69.0±8.8 years; age range, 42 to 85 years).
Results: The mean value of nitroglycerine-induced vasodilation in the brachial artery, left anterior descending coronary artery, and left circumflex coronary artery were 12.6±5.2%, 11.6±10.3%, and 11.9±11.0%, respectively. Nitroglycerine-induced vasodilation in the brachial artery correlated significantly with that in the left anterior descending coronary artery and that in the left circumflex coronary artery (Figure), with a significant correlation between nitroglycerine-induced vasodilation in the left anterior descending coronary artery and that in the left circumflex coronary artery (r=0.72, P<0.001).
Conclusions: Vascular smooth muscle cell dysfunction may be a systemic disorder and thus impairments of endothelium-independent vasodilation in peripheral and coronary arteries are simultaneously present. Nitroglycerine-induced vasodilation in the brachial artery could be used as a surrogate for that in coronary artery and as a prognostic marker for cardiovascular events.
Author Disclosures: T. Maruhashi: None. Y. Higashi: None. M. Kajikawa: None. A. Nakashima: None. Y. Iwamoto: None. A. Iwamoto: None. N. Oda: None. S. Kishimoto: None. S. Matsui: None. T. Higaki: None. T. Shimonaga: None. N. Watanabe: None. H. Ikenaga: None. T. Hidaka: None. Y. Aibara: None. K. Noma: None. Y. Kihara: None.
- © 2016 by American Heart Association, Inc.