Abstract 14213: QRS Duration and Risk of Atrial Fibrillation in the General Population
Introduction: Atrial fibrillation (AF) is a major predictor of cardiovascular morbidity and mortality. QRS duration (QRSd), a measure of ventricular conduction, also has been associated with an increased risk of poor outcomes, but its relationship with AF is currently unknown. To further improve our understanding of the pathophysiological correlates of AF, we investigated the relationship between QRSd and incident AF in the general population.
Methods: A total of 15,314 participants (54±5.8 years; 55% females; 26% black) from the Atherosclerosis Risk In Communities (ARIC) study without AF at baseline were included in this study. QRSd was automatically measured at a central electrocardiogram (ECG) reading core laboratory from baseline (1987-1989) resting 12-lead ECGs recorded using standardized methods. Incident AF cases were systematically ascertained using study ECGs, hospital discharge diagnoses or death certificates through 2010. Multivariable adjusted Cox regression analysis was performed to investigate the relationship between QRSd and incident AF.
Results: Over a median follow-up of 21.2 years (IQR 16.6 - 22.1), 2041 incident AF cases occurred. In multivariable Cox models, each 1-standard deviation of QRSd (12 ms) was associated with a 5% greater hazard of AF (hazard ratio (95% CI) 1.05 (1.01; 1.09), p=0.028). Results across clinically relevant categories of QRSd were similar and are presented in the Table.
Conclusion: In this large population based study, QRSd was an independent predictor of new-onset AF. These findings suggest that altered ventricular conduction, potentially related to diffuse modifications in the myocardial tissue, is associated with the development of AF.
Author Disclosures: S. Aeschbacher: None. W.T. O’Neal: None. P. Krisai: None. L. Loehr: None. L.Y. Chen: None. A. Alonso: None. E.Z. Soliman: None. D. Conen: None.
- © 2016 by American Heart Association, Inc.