Abstract 14186: Postoperative Change of Hemodynamics in Patient Specific Saphenous Vein Graft
Postoperative change of hemodynamics in patient-specific saphenous vein graft Tingting Fan1 and Yunlong Huo1 1Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, 100871, China
Introduction: The saphenous vein (SV) has been used as a coronary artery bypass graft because of its easy operability. The life span of SV graft (SVG) is, however, relatively shorter given complex changes of its hemodynamic parameters (e.g., wall shear stress-WSS, oscillatory shear index-OSI, spatial gradient of WSS-WSSG, and transverse WSS-transWSS) with postoperative time.
Hypothesis: We hypothesize that postoperative changes of atherosclerosis-prone flow patterns affect the graft patency significantly.
Methods: The objective of the study was to investigate the changes of hemodynamics in SVG and coronary arteries during the postoperative period of 1-10 years, based on patient-specific computer tomography angiography (CTA) images. A transient 3D finite volume model was used to solve the continuity and Navier-Stokes equations with the inlet and outlet boundary conditions of aortic pressure wave and flow resistance, respectively. Hemodynamic parameters were obtained from the computed flow field.
Results: High WSSG was found to be a dominant hemodynamic risk factor for the graft failure for ~1 year after surgical revascularization. A gradual increase of other atherosclerosis-prone parameters (e.g., low WSS and high OSI) deteriorated the hemodynamic environment in SVG and coronary arteries with postoperative time. (See Table-1)
Conclusions: Atherosclerosis-prone flow patterns changed over time after post-surgical revascularization. This reflects the interplay of hemodynamic and morphometric parameters postoperatively. These findings have significant implications on understanding graft patency as well as the design of SVG revascularization
Key Words: SVG, hemodynamics, postoperative years, graft patency
Author Disclosures: T. Fan: None. Y. Huo: None.
- © 2016 by American Heart Association, Inc.