Abstract 14184: Light to Moderate Alcohol Consumption Does Not Alter Endothelial Function
Light to moderate alcohol consumption does not alter endothelial function
Background: Light to moderate alcohol consumption has favorable effects on all caused death or coronary artery disease in women. Furthermore, light to moderate alcohol consumption decreases the blood pressure in women, while alcohol consumption is positively correlated with blood pressure in men. In the previous study, we have shown that even light to moderate alcohol consumption impairs endothelial function assessed by flow-mediated vasodilation (FMD) in men. It is expected that light to moderate alcohol consumption has beneficial effect on vascular function in women. There is little information on the relationship between alcohol consumption and endothelial function in women.
Methods and Results: We measured FMD in 702 women aged 17-86 years who provided the information on alcohol consumption. Alcohol consumption was positively correlated with high-density lipoprotein cholesterol, gamma glutamyl transpeptidase and uric acid in our study. There was no significant difference in FMD between non-drinkers and drinkers (p=0.96). Then we divided the subjects into 4 groups: non-drinkers (0 g/week), light drinkers (0< to 140 g/week), moderate drinkers (140< to 280 g/week) and heavy drinkers (>280 g/week). There were no significant difference in FMD among 4 groups (p=0.11). The numbers of moderate and heavy drinkers were not enough numbers to perform the multivariate regression analysis. Therefore, we compared 50 moderate drinkers and 50 age-, body mass index-, blood pressure- and medical conditions-matched non-drinkers, and 22 heavy drinkers and 22 non-drinkers matched pair analysis (1 drinker to 1 non-drinker). There was no significant difference in FMD between moderate drinkers and non-drinkers (8.2±4.3% v.s. 8.1±3.5, p=0.91), while FMD in heavy drinkers was significantly lower than non-drinkers (5.9±2.5% v.s. 8.9±3.5%, p=0.002).
Conclusion: These findings suggest that light to moderate alcohol consumption has no harmful effect on endothelial function, and that heavy alcohol consumption may impair endothelial function.
Author Disclosures: N. Oda: None. M. Kajikawa: None. T. Maruhashi: None. S. Kishimoto: None. S. Matsui: None. T. Hidaka: None. K. Noma: None. H. Tomiyama: None. B. Takase: None. A. Yamashina: None. Y. Higashi: None. Y. Kihara: None.
- © 2016 by American Heart Association, Inc.