Abstract 14159: Twenty Four-Hour Urinary Potassium Excretion, but not Sodium Excretion, Was associated With All-Cause Mortality in a General Population - the 27.5-year Prospective Data From the Tanushimaru Study
Introduction: Lower potassium consumption has been associated with hypertension and stroke. However, few studies have examined the relationship between urinary potassium and mortality, and most of them have been conducted by estimated 24-hour urinary potassium excretion from a morning urinary sample.
Hypothesis: The hypothesis of the present study is to investigate the association between 24-hour urinary potassium excretion and mortality in a healthy Japanese population using 24-hour urine collection.
Methods: The baseline study was conducted in 1978. A total of 1,291 participants (535 men, 756 women), aged 21 to 85 years, underwent health check-ups, which included blood chemistry measurements and the collection of 24-hour urine samples. Of the 1,291 participants who followed up for 27.5 years; the final follow-up rate was 95.8%. Cox’s proportional hazards models were used to assess the association between 24-hour urinary sodium or potassium excretion and all-cause mortality.
Results: At baseline, the mean 24-hour urinary sodium excretion was 5.80±2.28 g/day, and the mean 24-hour urinary potassium excretion was 1.85±0.82 g/day. There were 631 deaths: 153 (27%) from cancer, 77 (14%) from cardiovascular disease, 65 (12%) from stroke, 89 (16%) from infection and 173 (31%) from other causes. In the Cox’s proportional hazard model after adjustments for age and sex, 24-hour urinary potassium excretion was inversely associated with all-cause mortality (p=0.013). Even after adjustments for confounding factors, the significance of 24-hour urinary potassium excretion still remained (inversely; p=0.0006). Then, we divided the baseline 24-hour urinary potassium excretion levels into quartiles. After adjustments for confounding factors, the hazard ratio of all-cause mortality in the highest quartile of 24-hour urinary potassium excretion (>2.30g/day) vs. the lowest quartile (<1.28g/day) was 0.665 (95% C.I. 0.515-0.859, p=0.0015). However, no significant associations were found between 24-hour urinary sodium excretion and all-cause mortality.
Conclusion: This is the first report demonstrating that in the general population, 24-hour urinary potassium excretion was associated with all-cause mortality, while sodium excretion was not.
Author Disclosures: Y. Nohara: None. H. Adachi: None. M. Enomoto: None. A. Fukami: None. M. Otsuka: None. E. Kumagai: None. S. Nakamura: None. A. Obuchi: None. S. Kono: None. N. Morikawa: None. E. Nakao: None. A. Sakaue: None. T. Tsuru: None. Y. Fukumoto: None.
- © 2016 by American Heart Association, Inc.