Abstract 14100: Marijuana (Cannabis) Use is an Independent Predictor of Stress Cardiomyopathy in Younger Men
Background: Increased accessibility, recreational use and regional legalization of marijuana has been paralleled by widespread recognition of its serious cardiovascular complications (AMI, stroke, sudden death) particularly in the young. Cannabinoids have been implicated in pathogenesis of myocardial dysfunction through receptor and non-receptor mediated pathways. We aimed to examine trends in hospital admissions and outcomes of adults with transient ventricular regional ballooning (TVRB) in temporal relation to marijuana use.
Methods: Search of 2003-2011 Nationwide Inpatient Sample database identified 33,343 admissions for TRVB of which 210 (0.06%) were temporally related to active marijuana use. Demographics, clinical characteristics and outcomes of the two groups were compared.
Results: Marijuana users (MU) were younger (44±14-vs-66±13 years), more often male (36%-vs-8%), and had lower prevalence of hypertension (38%-vs-62%), diabetes (2.4%-vs-17.6%), and hyperlipidemia (15.7%-vs-52.4%) while more often suffered from depression (32.9%-vs-14.5%), psychosis (11.9%-vs-3.8%), anxiety disorder (28.4%-vs-16.2%), alcoholism (13.3%-vs-2.8%), tobacco use (73.3%-vs-28.6%) and poly-substance abuse (11.4%-vs-0.3%) [all p<0.001)]. MU more often suffered cardiac arrest and required placement of an ICD while congestive heart failure was more frequently observed in non-marijuana users (NMU) [Table]. Multivariable binary regression analysis on entire database (n=71,753,900), adjusted for known risk factors for TVRB, identified marijuana use as an independent predictor of TVRB [OR=1.994 (95% CI=1.716-2.317), p<0.0001].
Conclusions: Marijuana use is linked to TVRB in a distinct cohort of younger individuals and is associated with significant morbidity despite younger age and more favorable cardiac risk factor profile compared to TVRB in NMU.
Author Disclosures: A. Singh: None. S. Agrawal: None. M. Fegley: None. Y. Manda: None. S. Nanda: None. J. Shirani: None.
- © 2016 by American Heart Association, Inc.