Abstract 14093: Kidney Transplantation From Non-Hypertensive Unrelated Donor: Correction of Post-Transplant Hypertension
Introduction: Hypertension (HTN) is a very common even after successful kidney transplantation.
Hypothesis: Since hypertensive genotype may be transferred in kidney diseases, kidney from non-hypertensive donors may correct post-transplant HTN.
Method: A 103 kidney transplant recipients were review. There were 32 living-donor renal transplant (LDRT; 15 living-related and 17 living-unrelated) and 12 deceased donor renal transplant (DDRT) recipients, who received paired deceased donor kidneys (derived from the same donor transplanted to different recipients) leading to 5 “mate” recipient pairs.
Results: Of 44 recipients, mean age was 53.3 yrs old (21.4-79.5) and 57% were female. Median duration of follow-up was 8.2 mo (0.6-16.3). Mean serum creatinine (SCr) was 1.4±0.1 (LDRT 1.23±0.05 vs. DDRT 1.95±0.29, p=0.0006). Up to 93% had pre-transplant HTN, and 45% was non-hypertensive post-transplant (SBP≤140, DBP≤90, or being on ≤2 BP agents regardless SBP or DBP). Mean post-transplant SBP was not significantly lower than mean pre-transplant SBP(132.07±2.63 vs. 135±2.42, p=0.3526) as same as DBP(76.7±1.7 vs. 80±2.13,p=0.2406). Among 13 LRRT recipients with pretransplant HTN, 5 patients were non-hypertensive post-transplant; whereas 16 of 29 (55%) recipients of unrelated recipients (LURT+DDRT) became non-hypertensive (Figure1). Among 11 DDRT recipients with pretransplant HTN, only 4 patients (2 mate pairs) had the same post-transplant BP outcomes. The recipients with pre-transplant diabetes (DM) was account for 18%, and appears to have higher prevalence of post-transplant HTN compared to the non-DM recipients (75% vs. 39%, p=0.1148).
Conclusions: Pre-transplant HTN may be corrected by unrelated-donor kidney transplantation (LURT and DDRT). Un-expressed hypertensive phenotype of living-related donors may exist and using kidneys from living-related donors should be caution with the potential developing post-donation HTN in these donors.
Author Disclosures: E. Tantisattamo: Employment; Modest; William Beaumont Hospital. Consultant/Advisory Board; Modest; Scientific Advisory Board of the National Kidney Foundation of Michigan. W. Vutthikraivit: None. W. Sukhumthammarat: None. P. Putthapiban: None.
- © 2016 by American Heart Association, Inc.