Abstract 14066: Black-White Differences in the Influence of Risk Factors in Childhood on Left Ventricular Mass in Young Adulthood
Introduction: Cross-sectional studies have demonstrated a relationship between cardiovascular (CV) risk factors and left ventricular mass (LVM) in adolescents. Few data exist relating the burden of those risk factors over the childhood and young adult years on LVM, a known risk factor for hard CV events later in life.
Hypothesis: We sought to examine the relationship between CV risk factors, measured since age 10, and LVM/ht2.7 (LVMI) in adulthood in the National Growth and Health Study (NGHS), a longitudinal study examining the origins of racial differences in accumulation of adiposity and development of CV risk in girls.
Methods: A total of 556 girls (mean age 10.0 ± 0.5 years, 55.2% black, 45.8% white) had anthropometrics, blood pressure (BP), and labs performed at 17 yearly visits. LVMI was collected with 2-D guided echocardiographic imaging at a mean age of 26 years. Mean values at baseline and follow-up, and area under the curve (AUC) for CV risk factors, stratified by race, were examined by t-tests. General linear models were constructed to evaluate independent determinants of LVMI overall, and stratified by race. The initial full model contained race, BMI, percent body fat by skinfold (PBF), SBP, DBP, pulse, LDL, TG/HDL, HOMA and CRP.
Results: As seen previously, black girls had higher LVMI compared to whites. Blacks also had higher adiposity and insulin across time and lower TG/HDL ratio AUC (all p≤0.01). The major determinants of LVMI were (all AUCs): race, BMI z-score, SBP z-score, PBF, pulse and an interaction between race and pulse (model R2 = 0.40, p≤ 0.0001). Stratifying by race, pulse did not enter the model for blacks.
Conclusion: The major determinants of LVMI in young adult females are adiposity and SBP. The contribution of pulse to LVMI in whites may relate to previously noted higher sympathetic tone in obese whites. Efforts to prevent the development of obesity and hypertension in young girls are essential to reduce future hard CV events in adulthood.
Author Disclosures: B. Mendizabal: None. P.R. Khoury: None. J.G. Woo: None. E.M. Urbina: None.
- © 2016 by American Heart Association, Inc.