Abstract 14049: Outcomes of Post-operative Atrial Fibrillation After Lung Transplantation: A Meta-analysis.
Background: Post-lung transplantation atrial fibrillation is relatively common. The outcomes of such complication remain uncertain.
Objectives: To systematically evaluate the impact of post-lung transplant AF on mortality and hospital length of stay.
Methods: Electronic search of the MEDLINE and the Cochrane Library databases was conducted for studies that evaluated the outcomes of post-lung transplant AF. Random effects DerSimonian-Laird odds ratios (OR) were calculated. The main outcome was all-cause mortality.
Results: Nine trials were available for analysis with total of 2,097 patients. The mean age was 53.9 years, and 49.8% of the population were males. The incidence of post-lung transplant AF was 24.7%, occurring at mean duration of 6.4±2.6 days after surgery. Compared to the control group, the AF group were older age (p<0.001), predominantly males (p<0.001), with increased incidence of underlying HTN (p=0.003), CAD (p=0.008) and restrictive lung disease (p=0.002). Post-lung transplant AF was associated with increased risk of all-cause mortality compared with control group (OR 2.66; 95% CI 1.46-4.83; p=0.001) at mean follow-up duration of 12.8±9 months (Figure 1). Hospital length of stay was also increased in AF group compared with control group (Standardized mean difference (SMD) 0.40; 95% CI 0.19-0.62; p<0.001) (Figure 2).
Conclusions: Post-lung transplant AF might be associated with increased mortality and hospital length of stay. Randomized clinical trials are recommended for further evaluation of the outcomes of such complication.
Author Disclosures: M. Saad: None. A.Y. Elgendy: None. A. Mentias: None. A.F. Barakat: None. H.K. Abdelaziz: None. A. Abuzaid: None. I.Y. Elgendy: None. A.N. Mahmoud: None.
- © 2016 by American Heart Association, Inc.