Abstract 14030: The Impact of Arterial Stiffness on Long-term Clinical Outcomes in Patients at Low Risk of Cardiovascular Disease
Background: Brachial-ankle pulse wave velocity (PWV) is a simple method for assessing arterial stiffness. This study aimed to investigate the implication of PWV for predicting long-term clinical outcomes in patients at low risk of cardiovascular disease (CVD)
Methods: To evaluate the impact of arterial stiffness on long-term clinical outcomes in patients at low risk of CVD, we excluded patients having a history of cardiac and cerebrovascular disease, undergoing hemodialysis and showing abnormal ABI. We retrospectively evaluated the association between PWV and long-term clinical outcomes in 1886 patients, who underwent arterial plethysmography at admission. The endpoint of this study was major cardiovascular events (MACE) - a composite of cardiovascular death, myocardial infarction and ischemic stroke.
Results: During a median follow-up of 4.9 years, 119 patients had MACE. Patients with MACE exhibited significantly higher PWV values compared to those without MACE. Receiver operating characteristic (ROC) analysis revealed that optimal PWV cut-off value for MACE was 1803 cm/s. High PWV values (>1803 cm/s) significantly worsened patients’ MACE-free survival (log-rank p<0.001). Interestingly, high PWV values significantly worsened patients’ MACE-free survival in younger patients (<68 years: median age), whereas it did not in elderly patients. Moreover, multivariate cox regression analysis revealed that high PWV values was found to be an independent predictor of MACE in younger patients, but not in elderly patients (HR: 3.16, 95%CI: 1.60-6.22, p=0.001).
Conclusion: Evaluation of PWV may be useful for predicting MACE in younger patients at low risk of CVD in particular.
Author Disclosures: N. Abe: None. T. Miura: None.
- © 2016 by American Heart Association, Inc.