Abstract 13973: Time Course of Reverse Remodeling Following Catheter Ablation of Persistent Atrial Fibrillation
Introduction: Preservation of sinus rhythm following catheter ablation (CA) for persistent atrial fibrillation (PeAF) brings about structural reverse remodeling and recovery of cardiac function. However, the time course of reverse remodeling has not been well defined.
Purpose: This study aimed to evaluate the time course of echocardiographic parameters following CA of PeAF.
Methods: We enrolled 89 consecutive patients with PeAF undergoing CA. Patients with AF recurrence during the follow-up were excluded. Echocardiography was performed to evaluate the cardiac function on day 1, and 1, 3, and 6 months after CA.
Results: Forty-five patients who remained in sinus rhythm after ablation were included (69±6 years old, 40 (89%) males, AF duration 28.7±42.8 months, and CHADS2 score 1.8±1.1). The atrial filling velocity (A), peak mitral annular late diastolic velocity (a’) and deceleration time of the early diastolic filling velocity significantly increased for 1 month and then reached a plateau. Early diastolic filling velocity (E) and E/A ratio significantly decreased for 1 month and then reached a plateau. The left atrial volume index and left atrial dimension significantly decreased gradually until 3 months (Figure). The left ventricular end-diastolic and systolic dimensions, left ventricular ejection fraction, peak early diastolic velocity of the mitral annulus (e’), and raito of the E to e’ did not change significantly.
Conclusions: Preservation of sinus rhythm following PeAF CA brought about the hemodynamic reverse remodeling first, followed by the structural reverse remodeling.
Author Disclosures: T. Kanda: None. M. Masuda: None. M. Fujita: None. O. Iida: None. S. Okamoto: None. T. Ishihara: None. K. Nanto: None. A. Sunaga: None. T. Tsujimura: None. S. Okuno: None. Y. Masuda: None. K. Yanaka: None. T. Ohashi: None. H. Kawai: None. A. Tsuji: None. Y. Hata: None. M. Uematsu: None.
- © 2016 by American Heart Association, Inc.