Abstract 13925: Association of Ankle-Brachial Index With Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities (ARIC) Study
Introduction: A normal ankle-brachial index (ABI) is defined as 1.0 to 1.4; abnormal ABI is defined as ≤0.90 whereas >0.9 to <1.0 is considered “borderline” and >1.40 indicates noncompressible arteries. Although peripheral arterial disease has been shown to be associated with incident AF, it is unclear whether borderline ABI or noncompressible arteries are associated with incident AF. We aimed to evaluate this association of borderline ABI and ABI >1.4 in the ARIC study, a population-based prospective cohort study.
Methods: We included 14,794 participants (age, 54.2 ± 5.8 yrs, 55% women, 26% blacks) who attended the baseline exam (1987-89) and without prevalent AF. Incident AF was identified from hospital discharge records, death certificates, and ECGs. We used Cox proportional hazard models to evaluate the association between ABI categories and incident AF.
Results: During a mean follow-up of 19.8 years, there were 2288 incident AF cases. After full adjustment in Model 2, compared with ABI 1.0-1.4, the hazards ratio (HR) (95% CI) of ABI <1.0 for incident AF was 1.13 (1.01-1.27). ABI of >0.9 to <1.0, but not >1.4 was associated with an increased risk of AF (Table).
Conclusions: This study is the first to show that borderline ABI is independently associated with AF further supporting that borderline ABI is not benign. Our findings also suggest that detection of preclinical and early clinical atherosclerosis may identify individuals at increased risk of AF.
Author Disclosures: W. Bekwelem: None. F. Norby: None. S.K. Agarwal: None. K. Matsushita: None. J. Coresh: None. A. Alonso: None. L.Y. Chen: None.
- © 2016 by American Heart Association, Inc.