Abstract 13885: Excessive Daytime Sleepiness is Associated With Depression Scales but Not With Sleep Disordered Breathing in Patients Hospitalized With Cardiovascular Diseases
Background: Excessive daytime sleepiness (EDS) is a significant public health problem, and one of its most common causes is sleep disordered breathing (SDB), which is known to be associated with the development of cardiovascular disease. However, the relationship between EDS and SDB in patients hospitalized with cardiovascular diseases is unknown. The aims of this study were to assess the prevalence of EDS in cardiovascular patients, and examine its related factors including SDB and mental status.
Methods and Results: A total of 1783 patients (mean age, 65±15 years; 28.7% female) hospitalized for a spectrum of cardiovascular diseases in Keio University Hospital were enrolled (coronary artery disease n=564, arrhythmia n=658, heart failure n=137, valvular heart disease n=230, and other n=194). We assessed EDS using the Epworth sleepiness scale (ESS; mean 6.8±4.3), and EDS was defined as ESS>10 (n=335[18.8%]). We screened SDB using nocturnal pulse oximetry, a non-invasive method for detecting nocturnal intermittent hypoxia. The prevalence of SDB (3% oxygenation desaturation index>15/hour) did not differ between patients with EDS and those without (29% vs 29%, p=0.86). EDS was associated with younger age, alcohol use, higher eGFR, lower BNP level, and lower prevalence of hypertension, diabetics mellitus, and dyslipidemia (all p<0.05). Sex, BMI, and the prevalence of heart failure, coronary artery disease, or arrhythmia did not differ between patients with EDS and those without. The patients with EDS had significantly higher depression scales (Patient Healthcare Questionnaire [PHQ-9]; 5.2±4.6 vs 3.4±3.5, p<0.001, Hospital Anxiety and Depression Scale-Depression [HADS-D]; 5.5±4.0 vs 4.1±3.3 p<0.001). Multiple regression analysis revealed that depressive scales by PHQ-9 (OR=1.14; p=0.002; 95% CI, 1.05-1.24) and HADS-D (OR=1.16; p<0.001; 95% CI, 1.08-1.25) were independent determinants of EDS.
Conclusions: EDS is associated with depression symptoms, but not with SDB in patients admitted with cardiovascular diseases. These findings suggest that cardiovascular patients with EDS should be thoroughly assessed for depression.
Author Disclosures: M. Ohashi: None. T. Kohno: None. R. Noda: None. R. Matsuda: None. R. Fukuoka: None. S. Kohsaka: None. Y. Maekawa: None. M. Sano: None. S. Takatsuki: None. K. Fukuda: None.
- © 2016 by American Heart Association, Inc.