Abstract 13809: Soluble TNFα Receptor 1 Level Predicts Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis
Introduction: Heart failure(HF) is a common chronic disease with growing incidence and prevalence. Innate and adaptive immunity have important roles in initiation and progression of HF. Therefore we investigated the association of key biomarkers including soluble tumor necrosis α receptor 1 ( sTNFαR1; first-wave cytokine activity) and interleukin-2 receptor(sIL-2R; T cell activation) with incident HF in a population based cohort.
Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) is a population based study consisting of 6814 men and women free of clinical cardiovascular disease at enrolment recruited from four ethnicities in six US field centers. We included all participants with available sTNFαR1 and sIL-2R level measurements at baseline exam (n=2848). Both probable and definite HF were considered as the endpoint of the study. Cox Proportional Hazard models were used to evaluate the association of inflammatory biomarkers and time to first HF after adjusting for traditional risk factors for HF.
Results: The mean (SD) age was 61.6 (10.2) years and 46.4% were male. The median (IQR) sTNFαR1 (pg/ml) and sIL-2R (pg/ml) levels were 1292 (1107-1547) and 903 (727-1154). Over a median (IQR) follow up of 12.3 (11.6-12.8) years, 112 participants developed incident HF. Every 100 pg/ml higher sTNFαR1 level was associated with 5% higher risk of incident HF independent of traditional risk factors of HF (Table). The association with sIL-2R level was not statistically significant, although had a trend towards a modest association.
Conclusion: sTNFαR1 level is associated with future HF in a multi-ethnic population based cohort.
Author Disclosures: H. Bakhshi: None. B. Ambale-Venkatesh: None. Z. Meyghani: None. M.R. Ostovaneh: None. C.O. Wu: None. M. Cushman: None. R. Tracy: None. D.A. Bluemke: None. J.A. Lima: None.
- © 2016 by American Heart Association, Inc.