Abstract 13496: Impact of Serum Albumin Levels on Long-term Outcomes in Patients Undergoing Percutaneous Coronary Intervention
Background: Numerous studies have reported that lower serum albumin on heart failure is associated with increased adverse events. However, the relationship between albumin and long-term outcomes in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) is not well known.
Methods: We studied 2,860 all-comer patients with CAD who underwent their first PCI and available data of pre-procedural serum albumin between 2000 and 2011. Patients were assigned to tertiles based upon pre-procedural albumin levels. We evaluated the incidence of major adverse cardiac events (MACE) including all-cause death and acute coronary syndrome (ACS).
Results: The mean albumin level was 4.0±0.5 g/dL. Patients with a lower albumin levels were older and had a higher prevalence of ACS and chronic kidney disease (CKD). Patients with a higher albumin values were likely to be higher LVEF and had a higher prevalence of statin use. During a median follow-up period of 7.4 years, Kaplan-Meier curves showed ongoing divergence in rates of MACE among the albumin tertile groups (albumin <3.8g/dl: 44.3% vs. 3.8-4.1g/dl: 38.0% vs. >4.1g/dl: 22.9%; log-rank p<0.0001). After adjustment for established cardiovascular risk factors including age, ACS, BMI and CKD, serum albumin levels were significantly associated with incidence of MACE (HR 1.67 per each 1g/dl decrease, 95%CI 1.32-2.08, p<0.0001) and all-cause mortality (HR 1.75, 95%CI 1.30-2.33, p=0.0002).
Conclusions: Pre-PCI low serum albumin level was associated with worse long-term outcomes, independent of traditional risk factors. Assessing the albumin levels may have implications for risk stratification in patients with CAD undergoing PCI.
Author Disclosures: H. Wada: None. T. Dohi: None. K. Miyauchi: None. J. Shitara: None. H. Endo: None. S. Doi: None. R. Naito: None. H. Konishi: None. S. Tsuboi: None. M. Ogita: None. T. Kasai: None. S. Suwa: None. H. Daida: None.
- © 2016 by American Heart Association, Inc.