Abstract 13165: Comparison of Strut Coverage at 2 Weeks After Second and Third Generation DES Implantation in Patients With STEMI
Background: Third generation drug-eluting stent (DES) is characterized by thinner strut and abluminal coating with bioabsorbable polymer, and in vitro studies has demonstrated earlier endothelialization than previous generation of DES. However, whether this holds true also in human coronary is unknown.
Objective: Using optical coherence tomography (OCT), we compared strut coverage between 2nd generation DES (XIENCE) and 3rd generation DES (SYNERGY) at 2 weeks after stent implantation for ST-segment elevation myocardial infarction (STEMI).
Methods: Twenty-four patients with STEMI who were underwent primary percutaneous coronary intervention with XIENCE (n=14) or SYNERGY (n=10) were enrolled in this study. Angiographic and OCT were conducted at just after and 2 weeks after stent implantation. Two independent analysts who were blind to the clinical and stent information analyzed all images.
Results: A total of 4362 struts were analyzed in this OCT study. There was no difference between XIENCE and SYNERGY in percentage of malapposed struts (5.38% vs. 4.78%, p=0.81), percentage of residual thrombus (57.1% vs. 40.0%, p=0.43) and maximal thrombus area (0.20mm2 vs. 0.15mm2, p=0.61).
Percentage of strut coverage was significantly higher in SYNERGY than XIENCE (42.9% vs. 22.8%, p=0.0007).
Conclusion: At 2 weeks after stent implantation for STEMI lesions, increased strut coverage was observed in SYNERGY than XIENCE, suggesting earlier vascular healing after SYNERGY implantation.
Author Disclosures: M. Shimoda: None. H. Ando: None. A. Suzuki: None. S. Sakurai: None. A. Kurita: None. K. Waseda: None. H. Takashima: None. T. Amano: None.
- © 2016 by American Heart Association, Inc.