Abstract 13000: Physical Activity is Associated With Reduced Left Ventricular Mass Index in Blacks: Insights From the Genetic Epidemiology Network of Arteriopathy (GENOA) Study
Background: Physical activity (PA) has been associated with decreased left ventricular hypertrophy (LVH) in some clinical studies, however factors which influence this relationship have yet to be clarified. Blacks are disproportionately affected by cardiac diseases including LVH, partly due to higher rates of hypertension and obesity. Because other factors may also play a role, we investigated clinical factors that may affect the relationship between PA and LVH in blacks.
Methods and Results: We evaluated 1314 black participants with preserved LV ejection fraction (EF>50%) from the Genetic Epidemiology Network of Arteriopathy (GENOA) Study (mean age 62.4 years, 73% women). LV mass index (LVMI) was calculated from echocardiography using the Devereux formula and indexed by height2.7. Total hours of PA per day (TPA hours) were assessed by self-report. The relationship between TPA hours and LVMI was evaluated by generalized estimating equation (GEE) with identity link, and adjusted for possible confounders. The effect of TPA hours on LVMI by age group, sex, body mass index (BMI), history of hypertension, diabetes or coronary heart disease, estimated glomerular filtration rate and current smoking status were plotted. After adjustment for these factors, longer TPA hours were independently associated with lower LVMI (p<0.05). There were significant interactions between TPA hours and obesity (BMI≥30), and history of hypertension on LVMI (p for interaction <0.05, for both, Figure). Longer TPA hours were associated with lower LVMI more in obese or hypertensive participants compared to non-obese or non-hypertensive participants.
Conclusions: More PA was associated with lower LVMI in blacks. The protective effect of PA against LVH was present in obese and hypertensive black participants illustrating the importance of recommending increasing PA to prevent LVH and potentially reduce the risk of heart failure.
Author Disclosures: D. Kamimura: None. T. Suzuki: None. W. Wang: None. T.H. Mosley: Research Grant; Modest; U01-HL054463 (NIH). K.R. Butler: None. M.E. Hall: None.
- © 2016 by American Heart Association, Inc.