Abstract 12919: Co-aligned and Inherently Co-registered Intravascular Ultrasound and Optical Coherence Tomography in a Hybrid Imaging Catheter is Feasible for Characterizing Coronary Artery Disease
Introduction: Combined use of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) demonstrates synergistic benefits, which may improve the characterization and therapeutics of coronary artery disease. However, sequential use of stand-alone catheters is impractical.
Hypothesis: IVUS and OCT can be implemented in a dual-modality catheter with co-alignment of imaging beams, allowing simultaneous imaging of coronary lesions that are inherently co-registered.
Methods: A 3-French rotational custom hybrid IVUS-OCT imaging catheter was built using a 40 MHz ultrasound transducer with embedded OCT imaging fiber optics, as well as co-alignment of the IVUS and OCT imaging centers. Ex-vivo intraluminal IVUS and OCT images of 70 coronary artery segments from 5 cadaveric autopsies were acquired simultaneously at 25 frames/sec with 5 mm/sec pull back. Imaging at 100 frames/sec was also briefly conducted. Thirty segments had potential pathological findings and underwent histologic slicing and hematoxylin-eosin staining at 250μm intervals. Morphological features were identified based on standard criteria for IVUS and OCT, then compared to corresponding histology findings.
Results: IVUS and OCT were well co-registered based on fiduciary markings. A number of vascular pathologies were identified, including normal, fibrous, lipid-rich, calcified, and thrombus tissues. These findings were confirmed on corresponding histology. Complementary features of IVUS and OCT were also qualitatively apparent. IVUS showed deeper image depth to allow assessment of plaque size and vascular remodeling. OCT showed superior near field imaging, resolution and tissue contrast.
Conclusions: We demonstrated feasibility of co-aligning IVUS and OCT, providing co-registered hybrid images that highlight the complementary advantages of both modalities. Quantitative comparison and validation of this technology is on-going.
- Coronary artery disease
- Interventional cardiology
- Intravascular ultrasound/Doppler
- Vulnerable plaque
Author Disclosures: B.H. Li: Employment; Modest; Conavi Medical Inc.. Ownership Interest; Significant; Conavi Medical Inc. M. Harduar: Employment; Significant; Conavi Medical Inc. K. Virdi: Employment; Significant; Conavi Medical Inc.. J. Toma: None. N. Alves: None. B.K. Courtney: Employment; Significant; Conavi Medical Inc.. Research Grant; Significant; Canadian Institutes of Health Research, Canada Foundation for Innovation, Ontario Centres of Excellence, BioDiscovery Toronto, Ontario Research Fund, Health Technology Exchange (HTX) Ontario, FedDev Ontario. Ownership Interest; Significant; Conavi Medical Inc..
- © 2016 by American Heart Association, Inc.