Abstract 12768: Right Ventricular Mechanical Dyssynchrony in Pulmonary Hypertension is Associated With Right Ventricular Performance and Pulmonary Hemodynamics
Background: Right ventricular mechanical dyssynchrony (RVD) in pulmonary hypertension (PH) is prevalent and correlates with the extent of RV dysfunction and clinical worsening, but is not fully investigated. The aim of this study is to investigate clinical factors associated with RVD in patients with PH.
Methods: The study involved 24 patients (23 females; mean age of 62.2±17.5) with pre-capillary PH diagnosed by right heart catheterization, without electrocardiographic intraventricular conduction delay. They underwent determination of blood chemistry, magnetic resonance imaging and echocardiography including 2-dimensional speckle tracking. RVD was evaluated by 2-dimensional speckle-tracking echocardiography calculating the coefficient of variance of the times to peak-systolic strain for the 4 mid-basal RV segments (RV-CV4).
Results: Mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR) and RV-CV4 were 33.4±11.7 mmHg, 7.3±4.4 wood unit and 10.5±7.3,respectively. In univariate analyses, mPAP, PVR, RV-fractional area change (inversely), RV-ejection fraction (inversely) and uric acid were significant correlated with RV-CV4. Multivariate stepwise analysis revealed that uric acid was independently associated with RV-CV4 (R2=0.593).
Conclusion: The present study demonstrated that high uric acid level was a sole independent associate of RV dyssynchrony in PH patients, suggesting a predictor of heart failure and mortality.
Author Disclosures: S. Igata: None. N. Tahara: None. A. Tahara: None. A. Honda: None. Y. Nitta: None. Y. Sugiyama: None. B. Munehisa: None. T. Nakamura: None. J. Kumanomido: None. E. Kumagai: None. Y. Fukumoto: None.
- © 2016 by American Heart Association, Inc.