Abstract 12470: Carotid Intima-Media Thickness and Risk of Sudden Cardiac Death: The Atherosclerosis Risk In Communities (ARIC) Study
Introduction: Sudden cardiac death (SCD) has been a public health issue worldwide. Carotid intima-media thickness (C-IMT) is a known surrogate marker for atherosclerosis. Whether subclinical atherosclerosis is associated with risk of SCD remains unknown especially in a middle-aged general population.
Methods: We investigated the associations of C-IMT with SCD through 2012 among 15,307 blacks and whites participants at the first visit (1987-1989) of the community based-ARIC study. C-IMT (mean and maximum of C-IMT and common carotid artery (CCA)-IMT) was measured at the first visit by ultrasound. Presence of plaque was judged by trained readers and defined as two of the following three criteria: abnormal wall thickness (defined as C-IMT >1.5 mm), abnormal shape (protrusion into the lumen and loss of alignment with adjacent arterial wall boundary), and abnormal wall texture (brighter echoes than adjacent boundaries). Kaplan-Meier curves and Cox proportional hazards models were used to evaluate associations of incident SCD with baseline C-IMT.
Results: Over a median of 23.48 years of follow-up, 569 participants had SCD (37 cases per 1,000 person-years). C-IMT was associated with risk of SCD after adjustment for traditional risk factors (Figure and Table). Presence of plaque was associated with risk of SCD (HR 1.55; 95% CI 1.28-1.86, P<0.001).
Conclusion: Subclinical atherosclerosis measured by C-IMT was associated with risk of SCD in a middle-aged general population. These results may suggest importance of subclinical atherosclerosis in SCD risk and lead to early therapeutic intervention to prevent SCD.
Author Disclosures: T. Suzuki: None. W. Wang: None. A. Wilsdon: None. K.R. Butler: None. S. Adabag: None. M.E. Griswold: None. V. Nambi: None. W. Rosamond: None. N. Sotoodehnia: None. T.H. Mosley: None.
- © 2016 by American Heart Association, Inc.