Abstract 12105: Temperature Variability During Targeted Temperature Management is not Associated With Neurological Outcomes following Cardiac Arrest
Introduction: Recent studies on comatose survivors of cardiac arrest undergoing targeted temperature management (TTM) have reported similar outcomes at multiple target temperatures. However, details regarding core temperature variability during TTM and its prognostic implications remain unknown.
Hypothesis: Increasing core temperature variability during TTM will predict poor neurological outcomes.
Methods: We analyzed a prospectively collected cohort of 242 consecutive comatose survivors of cardiac arrest treated with TTM at a tertiary care hospital between 2007 and 2014. Core temperature variability was defined as the statistical variance (i.e. standard deviation squared) amongst all core temperature recordings during the maintenance phase of TTM. Poor neurological outcome at hospital discharge, defined as a Cerebral Performance Category (CPC) score >2, was the primary outcome. Death prior to hospital discharge was assessed as the secondary outcome.
Results: Baseline patient characteristics are reported in Table 1. A poor neurological outcome was observed in 147 (61%) patients and 136 (56%) patients died prior to hospital discharge. In multivariable logistic regression, increased core temperature variability was not associated with increased odds of poor neurological outcomes (OR 0.38, 95% CI 0.11-1.38, p=0.142) or death (OR 0.43, 95% CI 0.12-1.53, p=0.193) at hospital discharge.
Conclusions: In this study, individual core temperature variability during TTM was not associated with poor neurological outcomes or death at hospital discharge.
Table 1. Baseline characteristics and clinical features. Data are presented as median (IQR) for continuous variables and number (percentage) of patients for categorical variables. N represents the number of non-missing values.
CPR, cardiopulmonary resuscitation; ROSC, return of spontaneous circulation; TTM, targeted temperature management.
Author Disclosures: A. Nayeri: None. N. Bhatia: None. B. Holmes: None. N. Borges: None. W. Armstrong: None. M. Xu: None. E. Farber-Eger: None. Q. Wells: None. J. McPherson: None.
- © 2016 by American Heart Association, Inc.