Abstract 12025: Higher Lactate Oxygen Index Rather than Artery Lactate Indicate Poor 24h-survival After Resuscitation in a Porcine Model of Prolonged Cardiac Arrest
Introduction: Increases in arterial lactate concentration (ALac) and cerebral lactate oxygen index (LOI) are documented indicators of poor prognosis in critically ill patients. In the present study, we investigated the changes of ALac and LOI after successful cardiopulmonary resuscitation (CPR) in a porcine model of prolonged cardiac arrest (CA).
Hypothesis: Lactate oxygen index serves as a more sensitive indicator of post resuscitation survival than arterial lactate.
Methods: Twelve male domestic pigs weighing 40 ± 3kg were studied. Ventricular fibrillation was electrically induced and untreated for 10 min. All animals were successfully resuscitated. Blood gas samples were obtained from the internal jugular vein and abdominal descending aorta at baseline (BL), 30 min and 120 min after resuscitation (PR). LOI was calculated based on the arterial (CaO2) and jugular venous oxygen (CjO2) content: CaO2 = (1.34 х Hb х SaO2) + (0.003 х paO2), CjO2 = (1.34 х Hb х SjO2) + (0.003 х pjO2), LOI = -(arterial lactate-jugular vein lactate)/(CaO2-CjO2).
Results: Five animals died in <24 h after initial resuscitation and the other seven survived > 24 h. The level of ALac in all animals increased significantly at PR30 and returned to BL at PR120. No significant differences in ALac were observed between survivors and non-survivors. LOI was increased in all animals after resuscitation when compared with BL. We observed significantly higher LOI levels at PR30 and PR120 in non-survivors vs. survivors.
Conclusions: Higher LOI levels after resuscitation indicate poor 24 h survival in a pig model of prolonged CA.
Author Disclosures: X. Zhai: None. Z. Yang: None. L. Jiang: None. C. Wen: None. H. Zheng: None. T. Yu: None. M.A. Peberdy: None. J. Ornato: None. W. Tang: None.
- © 2016 by American Heart Association, Inc.