Abstract 11980: National Trends and In-hospital Outcomes During Delivery in Pregnant Women With Heart Disease in the US
Background: Investigation of trends and outcomes in heart disease (HD) and pregnancy has been limited.
Objective: We chose to investigate the temporal trends and outcomes of pregnancy in women with HD in the US from 2003-2012.
Methods: Healthcare Cost and Utilization Project’s National Inpatient Sample was screened for hospital admissions for delivery in pregnant women with HD from 2003-2012. Maternal clinical characteristics and outcomes were identified in women with and without HD, and in HD subtypes: congenital (CHD), valvular (VHD), cardiomyopathy (CDM), and pulmonary hypertension (PH). Primary outcomes of interest were prevalence, trends, and major adverse cardiac events (MACE), a composite of in-hospital death, acute myocardial infarction, heart failure, arrhythmia, cerebrovascular event, embolic events, or cardiac complications of anesthesia.
Results: We studied 81,295 patients with HD and 39,894,032 without. CHD was the most frequent type (41.8%, 33,982 of 81,295), followed by VHD (30.9%, 25,138 of 81,295), CDM (20.8%, 16,926 of 81,295) and PH (6.5%, 5,250 of 81,295). MACE was highest among women with CDM and lowest in CHD (44.0%, 7,449 of 16,926 vs 6.2%, 2,102 of 33,982 p<0.0001). PH patients had the highest in-hospital death, followed by CDM (1.0%, 51 of 5,250 and 0.7%, 124 of 16,926 respectively). Pregnant women with HD significantly increased by 24.7%, related to increases in CDM, CHD, and PH. MACE significantly increased by 18.8%.
Conclusions: Pregnancy in women with heart disease is increasing, particularly for high risk conditions such as CDM and PH. There is a significant and gradual increase in MACE for women with heart disease.
Author Disclosures: P. Koutrolou-Sotiropoulou: None. F.V. Lima: None. J. Yang: None. J. Xu: None. K. Stergiopoulos: None.
- © 2016 by American Heart Association, Inc.