Abstract 11979: Relationship between the QT Interval and Outcome in Low-Flow Low-Gradient Aortic Stenosis With Low LVEF
Background: The QT interval has been shown to be associated with cardiovascular events. There is no data available on the association between the QT interval and left ventricular (LV) function and on its impact on prognosis in patients with low LV ejection fraction (LVEF), low-flow, low-gradient (LF-LG) aortic stenosis (AS). The objectives of this study were to examine the relationship between the corrected QT interval (QTc) and LV function and outcome in patients with LF-LG AS and low LVEF.
Methods: Ninety-three patients (73±10 years; 74% men) with LF-LG AS (i.e. mean gradient [MG] <40 mmHg and indexed aortic valve area [AVAi] ≤0.6 cm2/m2) and reduced LVEF (≤40%) were prospectively included in this analysis and 63 (68%) of them underwent aortic valve replacement (AVR) within 3 months following inclusion. QTc was calculated with the Bazett formula. Prolonged QTc was defined as QTc> 450 ms in men and >470 ms in women. The severity of AS was assessed by the projected AVA (AVAproj) at normal flow rate. LV global longitudinal strain (GLS) was measured by 2D speckle tracking and expressed in absolute value
Author Disclosures: A. Dahou: None. O. Toubal: None. M. Clavel: None. J. Beaudoin: None. J. Magne: None. P. Mathieu: None. F. Philippon: None. J.G. Dumesnil: None. R. Puri: None. H.B. Ribeiro: None. É. Larose: None. J. Rodés-Cabau: None. P. Pibarot: None.
- © 2016 by American Heart Association, Inc.