Abstract 11894: Deficiencies of Water-soluble Vitamin Intake Predict Shorter Event-free Survival in Patients With Heart Failure
Introduction: Water-soluble vitamins play an important role in producing adenosine triphosphate and decreasing oxidative stress. Because water-soluble vitamins are not stored, inadequate dietary intake leads to water-soluble vitamin deficiencies, which may be associated with adverse health effects. Patients with heart failure (HF) are at risk for water-soluble vitamin deficiencies even if their water-soluble vitamin intakes meet dietary recommended intake as diuretics are routinely prescribed to this population. However, there are few studies, which have measured the relationship between deficiencies of water-soluble vitamin intake and outcomes in HF.
Purpose: To determine whether deficiencies of water-soluble vitamin intake predicted event-free survival in patients with HF
Methods: Using a prospective, observational study design, patients with HF were recruited from HF clinics. A total of 216 patients with HF (61years; 34.3% female; 53.7% NYHA I/II; 71.8% LVEF ≤ 40%) were included in this analysis. Four-day food diary analyzed by Nutrition Data System-Research software was used to determine water-soluble vitamin dietary deficiencies (i.e., 8 B vitamins and vitamin C). Event-free survival was defined as a composite endpoint of all-cause death, cardiac hospitalization, or emergency department visit for cardiac reasons. Monthly calls to patient or family and medical record reviews were used to determine event-free survival for 12 months.
Results: The average number of water-soluble vitamin deficiencies was 1 (SD 1.24) with the range of 0 -7. There were 63 events during the median follow-up of 356 days. Multivariable Cox regression showed that each unit increase in the number of water-soluble vitamin deficiencies was associated with a 1.3-fold increase in risk for an event (95% CI 1.02-1.66), after adjusting for age, gender, NYHA functional class, reduced LV function (i.e., LVEF≤ 40%), N-terminal pro B-type natriuretic peptide, total comorbidities, and use of diuretics (yes/no).
Conclusions: Deficiencies of water-soluble vitamin intake were associated with a shorter event-free survival in patients with HF. This result suggests a potential benefit to correcting water-soluble vitamin deficiencies in this population.
Author Disclosures: K. Lee: None. J. Park: None. D.K. Moser: Research Grant; Significant; NINR. S.B. Dunbar: None. S.J. Pressler: None. T.A. Lennie: Research Grant; Significant; NINR.
- © 2016 by American Heart Association, Inc.