Abstract 11891: Nitroglycerin Improves Microcirculation During and After Cardiopulmonary Resuscitation in a Porcine Model of Cardiac Arrest
Introduction: We have previously demonstrated that vasopressors administered during cardiopulmonary resuscitation (CPR) significantly decrease microcirculatory flow. In the present study, we investigated the effects of nitroglycerin on the macrocirculation macro and microcirculation and microcirculation during and after CPR in a porcine model of cardiac arrest (CA).
Hypothesis: Nitroglycerin improves microcirculation but without undesirable effects on the macrocirculation during and after resuscitation.
Methods: Ten male domestic pigs weighing 40±2 kg were utilized. Ventricular fibrillation was electrically induced and untreated for 5 min. The animals were then randomized to receive NTG (N group) or saline (C group). Coincident with the start of CPR, NTG (5 μg/kg) or saline was administrated into the right atrium. Defibrillation was attempted by a single 150 J shock after 5 min of CPR. Hemodynamics were recorded continuously and sublingual microcirculation was assessed with the orthogonal polarisation spectral (OPS) at baseline (BL), 1, 5 min of CPR and 1, 5 min after resuscitation.
Results: All animals were resuscitated successfully resuscitated. There were no differences in coronary perfusion pressure (CPP), end-tidal carbon dioxide (ETCO2) between the two groups (Figure 1). Sublingual perfused vessel density (PVD) and microcirculatory flow index (MFI) were significantly better in NTG treated animals than those of control animals during and after CPR.
Conclusion: Administration of nitroglycerin at the onset of CPR improves microcirculation without undesirable effects on macrocirculation during and after resuscitation.
Author Disclosures: C. Miao: None. Z. Yang: None. C. Wen: None. X. Zhai: None. T. Yu: None. M.A. Peberdy: None. J.P. Ornato: None. W. Tang: None.
- © 2016 by American Heart Association, Inc.