Abstract 11635: Non-Alcoholic Fatty Liver Disease and Subclinical Atherosclerosis in Mexican Americans
Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of the metabolic syndrome, whose criteria are risk factors for atherosclerotic CVD. We aimed to evaluate the prevalence of NAFLD, its association with subclinical atherosclerosis, and factors that may account for this association in Mexican Americans.
Methods: In a population based cross-sectional sample (n=164) drawn from the Cameron County Hispanic Cohort in Texas, carotid intima media thickness (cIMT), an indicator of subclinical atherosclerosis, was measured by ultrasound. Abnormal carotid study was defined as mean cIMT >75th percentile for age and gender and/or plaque presence. NAFLD was defined as steatosis by ultrasound in absence of other causes of liver disease. Multivariable weighted regression analyses were performed to evaluate associations between NAFLD and cIMT.
Results: Mean age was 50.3±1.8 years with 60% females. Mean BMI was 30.1 ± 0.4 kg/m2 with 61% meeting criteria for the metabolic syndrome. There was a very high prevalence of NAFLD (49%) among Mexican Americans. Subjects with NAFLD had greater BMI, abdominal obesity, fasting glucose levels, dyslipidemia, and tended to have diabetes or metabolic syndrome. A third of subjects with NAFLD also had evidence of subclinical atherosclerosis (33%). After adjusting for covariates, there was an independent association between NAFLD and increased cIMT, but only in younger subjects <55 years (p=0.02). Subjects who had both abnormal liver and carotid ultrasound studies tended to be obese, diabetic, and have the metabolic syndrome.
Conclusion: There is a very high prevalence of NAFLD in this Mexican American cohort, with an independent association between NAFLD and subclinical atherosclerosis among younger subjects. Clustering of diabetes, obesity, and metabolic syndrome in this health disparity cohort, with increased risk of both liver disease and atherosclerosis, warrants attention and aggressive intervention.
- Subclinical atherosclerosis
- Carotid intima-media thickness (CIMT)
- Metabolic syndrome
Author Disclosures: C.D. Gill: None. K.P. Vatcheva: None. J. Pan: None. B. Smulevitz: None. M.B. Fallon: None. D.D. McPherson: None. J.B. McCormick: None. S.P. Fisher-Hoch: None. S.T. Laing: None.
- © 2016 by American Heart Association, Inc.