Abstract 11363: Association of Dietary Protein, Animal and Vegetable Protein With the Incidence of Heart Failure Among Postmenopausal Women
Background: Heart failure (HF) is a highly prevalent disease especially in post-menopausal women. A better understanding of nutrition-related factors associated with HF is needed. Misclassification of diet due to self-reports can be partially ameliorated by use of biomarker calibration equations.
Objectives: This study evaluated prospectively the association between biomarker calibrated dietary protein intake and the incidence of heart failure in a cohort of postmenopausal women. In addition, we studied the effect of energy adjusted animal and plant based dietary protein and the incidence of HF.
Methods: Study participants are postmenopausal women (n=103,878) who are free of Heart Failure at baseline, evaluated from 1993-1998 in the Women health Initiative (WHI). We used self-reported intakes of total dietary protein, animal protein, and vegetable protein based upon a Food Frequency Questionnaire (FFQ) and calibration equations for protein derived from urinary nitrogen excretion and energy calibration based upon doubly labeled water. The association between dietary protein intake and the incidence Heart Failure was evaluated using cox proportional hazards models, and treating age as a continuous variable within age strata due to Simpson’s paradox.
Results: Among 103,878 women in the study sample, 1711 women developed HF through 2005. Incremental biomarker calibrated dietary protein consumption was associated with an increase in the risk for Heart Failure. An inverse association was found between higher intakes of energy adjusted vegetable protein and HF although this association wasn’t statically significant if the association was adjusted to BMI and diet quality.
Conclusion: Higher total dietary protein intake (calibrated), appears to be associated with substantially increased heart failure risk while the vegetable protein intake appears to be protective against developing Heart Failure. Further studies are needed to explore this association.
Author Disclosures: M. Barbour: None. F. Ashraf: None. M. Roberts: None. M. Allison: None. L. Martin: None. K. Johnson: None. C. Valdiviezo: None. C. Eaton: None.
- © 2016 by American Heart Association, Inc.