Abstract 11328: Impact of Periodontitis on Long-term Clinical Outcomes in Patients With Atrial Fibrillation
Introduction: Relationship between atrial fibrillation (AF) and inflammation was shown in previous studies.
Hypothesis: However, there was limited data about the association between the periodontitis and atrial fibrillation in the long-term follow up. The aim of this study was to evaluate the impact of periodontitis on long-term clinical outcomes in patients with AF.
Methods: The Kosin University echocardiography, electrocardiogram (ECG) and periodontitis database were reviewed from 2010 to 2015 to identify patients with AF and periodontitis. Patients were followed for a median of 2.1 years and were divided into two groups according to the absence or presence of periodontitis in patients with AF.
Results: Among 227 patients with AF, 47 (20.7%) patients had periodontitis. Total any event rates were significantly higher in patients with periodontitis compared to those without periodontitis (P<0.001). Arrhythmias including AF, atrial tachycardia, atrial premature beat, ventricular tachycardia, and ventricular premature beat also occurred in 36 patients, with a significantly higher incidence in patients with periodontitis than in those without periodontitis (P<0.001). In univariate analysis, age, CHA2DS2 VASc, Left atrial volume index (LAVI) and periodontitis were significantly associated with arrhythmic events and total any events including bleeding events, thromboembolic events, arrhythmic events, re-hospitalizations and mortality. In multivariate analysis, LAVI (P=0.005) and periodontitis (P<0.001) were independent risk factors for arrhythmic events and periodontitis (P<0.001) for total any events at the long-term follow-up.
Conclusions: The patients with periodontitis were associated with higher total any events and arrhythmic events, suggesting more intensive medical therapy with close clinical follow-up will be required.
Author Disclosures: S. Im: None.
- © 2016 by American Heart Association, Inc.