Abstract 11153: Association of β1-Adrenergic,M2-Muscarinic Receptor Autoantibody With Occurrence of Nonvalvular Atrial Fibrillation
Introduction: Atrial fibrillation (AF) is the most common sustained arrhythmia and confers an independent increased risk of stroke and death. Although the exact mechanisms behind AF are not completely elucidated, A large number of evidence demonstrates that autoimmunity may play an important role in the initiation, the progression and the maintenance of AF.
Hypothesis: In this study, we aimed to compare anti-β1-R and anti-M2-R levels between non-valvular AF patients and healthy control subjects
Methods: Seventy-one patients with non-valve atrial fibrillation(age: 62.69±11.23 years, 54% male),along with 71healthy control subjects(age: 61.86±11.90 years, 52% male) were included . Enzyme-linked immunosorbent assay tests to measure serum anti-β1-R and anti-M2-R levels were performed in both groups. Hs-CRP concentration was measured by immunoturbidimetry.IL-6 concentration was measured by chemiluminescence.
Results: Anti-β1-R and anti-M2-R levels were significantly higher in patients with non-valvular AF compared to healthy controls[anti-β1-R 221.11(132.38-291.69) vs. 198.14(125.70-278.40) ng/ml, P<0.01; anti-M2-R 271.81(144.99-378.20) vs. 235.01(121.53-358.99) ng/ml, P<0.01]. Compared with the control group, the serum level of IL-6,hs-CRP were higher in the non-valvular AF group(IL-6 19.65±5.6pg/mL vs 6.79±1.09pg/mL,hs-CRP 6.03±1.35mg/Lvs 2.73±0.63mg/L P<0.05).After multivariable analyses , the baseline value of serum anti-β1-R (OR: 13.176, p<0.001),anti-M2-R (OR:4.41, p<0.001),IL-6(OR:6.126, p<0.05) levels and LA diameter(OR:5.781, p<0.05) were independently predictors of non-valvular AF.
Conclusions: We found a significant association between circulating serum anti-β1-R,anti-M2-R,IL-6 levels and non-valvular AF. The possible mechanism is that the autoimmunity and inflammation might take part in electrical remodeling and structural remodeling of left atrium. Larger studies are warranted to further investigate their role in these settings.
Author Disclosures: B. Hu: None. Y. Sun: None. S. Li: None. J. Sun: None. T. Liu: None. Z. Wu: None. L. Feng: None.
- © 2016 by American Heart Association, Inc.