Letter by Kataoka et al Regarding Article, “Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle”
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To the Editor:
We read the recent article by van der Bruggen et al1 published in Circulation with great interest. In their study, right ventricular (RV) function was investigated in 95 patients with idiopathic or familial pulmonary arterial hypertension (PAH), in whom 28 patients (29.5%) had a BMPR2 mutation and 67 patients (70.5%) did not. Interestingly, despite a similar afterload, RV function was more severely impaired in the mutation carriers compared with the noncarriers, and importantly, the differences in RV function between carriers and noncarriers continued to exist after treatment. …