Response by Lai and Gladwin to Letter Regarding Article, “SIRT3-AMP–Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction”
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
We certainly agree with Drs Carlström and Lundberg that the nitrate–nitrite–nitric oxide (NO) pathway appears to activate AMP kinase (AMPK) signaling networks in the vascular system and skeletal muscle.1–3 It is all the more remarkable considering the fact that exercise, fasting, and metformin activate these pathways, suggesting that nitrite signaling may represent a convergent signaling pathway underlying these physiological stressors and drug, potentially via the intermediacy of NO synthase–dependent NO generation and secondary oxidation to more stable reservoirs of nitrite and nitrate. Interestingly, Drs Carlström and Lundberg recently reported that short-term treatment …