Letter by Mezue et al Regarding Article, “Effect of Intensive Versus Usual Blood Pressure Control on Kidney Function Among Individuals With Prior Lacunar Stroke: A Post Hoc Analysis of the Secondary Prevention of Small Subcortical Strokes (SPS3) Randomized Trial”
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To the Editor:
We read the recent article by Peralta et al1 that was published in Circulation with great interest. In their post hoc analysis of the SPS3 study (Secondary Prevention of Small Subcortical Strokes), they found that, in patients with a prior lacunar stroke, treating to lower systolic blood pressure (SBP) targets (SBP<120 mm Hg) led to a higher likelihood of rapid kidney function decline, although this decline was not associated with worse cardiovascular outcomes. They also found that, …