Letter by Rajapakse et al Regarding Article, “Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition”
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To the Editor:
We read the review article entitled “Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition” with great interest.1 As alluded to by the authors themselves, one of the potential concerns of this therapy relates to reduced amyloid-β plaque degradation resulting from neprilysin inhibition. Amyloid-β deposition in the brain plays a central role in the pathogenesis of Alzheimer disease. …