Response by Hubers and Brown to Letter Regarding Article, “Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition”
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We thank Rajapakse et al for expanding on our point about the role of neprilysin in amyloid-β degradation from our review article on combined angiotensin receptor antagonism and neprilysin inhibition.1 Rajapakse et al raised the concern that neprilysin inhibition may predispose patients to Alzheimer disease because of decreased degradation of amyloid-β, a key component of the neural plaques and deposits diagnostic of the disease. Therefore, it …