Response by Li et al to Letter Regarding Article, “Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria Due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart”
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We thank Dr He for his comments on our study1 and for the interesting points he raises.
In our functional and molecular mapping study1 of human hearts ex vivo, we demonstrated that adenosine provokes atrial fibrillation (AF) with a higher activation frequency in the right atria versus the left atria because of localized reentrant drivers in the lateral right atria. Furthermore, our study revealed a high right atria-to-left atria protein expression …