Response by Menon et al to Letter Regarding Article, “Analysis of Workflow and Time to Treatment on Thrombectomy Outcome in the Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke (ESCAPE) Randomized, Controlled Trial”
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We thank Venema et al for the interest they showed in our article.1 We agree with them that any time saved helps improve clinical outcome in patients with acute ischemic stroke. The ESCAPE trial (Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke) was based on the concept that imaging is a snapshot in time of brain physiology.2 Time from stroke onset is another measure of brain physiology. Stroke onset time is often imprecisely measured, especially in patients who either wake up with stroke symptoms or have unwitnessed stroke onset. These errors with onset time measurement are all the more relevant in the ESCAPE trial, which enrolled patients ≤12 hours from stroke symptom onset. …