Abstract P287: The Association Between Usual Fast Food Intake Over 25 Years and Non-alcoholic Fatty Liver Disease: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Introduction: Nonalcoholic Fatty Liver Disease (NAFLD) is a common obesity related complication that is strongly associated with cardiometabolic morbidity. Despite being a major cardiometabolic risk factor, there is minimal understanding of the relationship between modifiable factors such as diet with NAFLD. Therefore, we examined the association between usual fast food intake habits over 25 years beginning in young adulthood and the odds of having NAFLD during middle age.
Hypothesis: A higher average frequency of visits to fast food restaurants over 25 years is positively associated with NAFLD.
Methods: We analyzed data from the CARDIA study and included participants with at least 2 assessments of fast food restaurant visit frequency (assessed exam year 0, 7, 10, 15, 20, 25) over 25 years and Computed Tomography (CT) quantification of liver fat at the year 25 exam (age 43-55 years). NAFLD was defined as liver attenuation ≤ 40 Hounsfield units after the exclusion of other causes of liver fat (e.g. heavy alcohol use). Logistic regression models were used to test the association between the average fast food restaurant visit frequency and NAFLD. This analysis includes 2,682 participants.
Results: The prevalence of NAFLD at year 25 was 9.8% (264/2682). There was a strong positive association between higher fast food restaurant visit frequency over 25 years and the odds of NAFLD independent of sugar and artificially sweetened beverages, overall diet, and relative lifestyle factors (Table). This association was still positive after adjustment for BMI at year 25. Results were consistent by sex, race, and BMI.
Conclusions: These results underscore how a higher usual frequency of fast food intake from early adulthood through middle age is positively associated with NAFLD during middle age, and driven by but not dependent on higher levels of relative weight.
Author Disclosures: A.O. Odegaard: None. D.R. Jacobs: None. L.M. Steffen: None. M.A. Pereira: None.
- © 2016 by American Heart Association, Inc.