Skip to main content
  • American Heart Association
  • Science Volunteer
  • Warning Signs
  • Advanced Search
  • Donate

  • Home
  • About this Journal
    • Editorial Board
    • General Statistics
    • Circulation Doodle
      • Doodle Gallery
      • Circulation Cover Doodle
        • → Blip the Doodle
    • Information for Advertisers
    • Author Reprints
    • Commercial Reprints
    • Customer Service and Ordering Information
    • Subscribe to AHA Journals
  • All Issues
  • Subjects
    • All Subjects
    • Arrhythmia and Electrophysiology
    • Basic, Translational, and Clinical Research
    • Critical Care and Resuscitation
    • Epidemiology, Lifestyle, and Prevention
    • Genetics
    • Heart Failure and Cardiac Disease
    • Hypertension
    • Imaging and Diagnostic Testing
    • Intervention, Surgery, Transplantation
    • Quality and Outcomes
    • Stroke
    • Vascular Disease
  • Browse Features
    • AHA Guidelines and Statements
      • Recently Published Guidelines
    • Bridging Disciplines
    • Circulation at Major Meetings
    • → Articles Bridging Discplines
    • Special Themed Issues
    • Global Impact of the 2017 ACC/AHA Hypertension Guidelines
    • Circulation Supplements
    • Cardiovascular Case Series
    • ECG Challenge
    • Hospitals of History
      • Brigham and Women's Hospital
      • Hartford Hospital
      • Hospital Santa Maria del Popolo, Naples, Italy
      • Instituto do Coração-INCOR (São Paulo, Brasil)
      • Minneapolis City Hospital
      • Parkland Hospital: Dallas, Texas
      • Pennsylvania Hospital, Philadelphia
      • Pitié-Salpêtrière Hospital
      • Royal Infirmary of Edinburgh, Scotland
      • Tufts Medical Center
      • University of Michigan
      • Uppsala University Hospital
      • Vassar Brothers Medical Center (Poughkeepsie, NY)
      • Wroclaw Medical University
      • Women's College Hospital, Toronto, Canada
      • Henry Ford Hospital, Detroit, Michigan
      • Instituto Nacional de Cardiología Ignacio Chávez – INCICh México City, México
      • Kuang-Tien General Hospital (Taichug, Taiwan)
    • On My Mind
    • Podcast Archive
    • → Subscribe to Circulation on the Run
    • →Circulation FIT Podcast 2018
    • → #FITFAVs
  • Resources
    • Instructions for Authors
      • Accepted Manuscripts
      • Revised Manuscripts
    • → Article Types
    • → General Preparation Instructions
    • → Research Guidelines
    • → How to Submit a Manuscript
    • Journal Policies
    • Permissions and Rights Q&A
    • Submission Sites
    • Circulation CME
    • AHA Journals RSS Feeds
    • International Users
    • AHA Newsroom
  • AHA Journals
    • AHA Journals Home
    • Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
    • Circulation
    • → Circ: Arrhythmia and Electrophysiology
    • → Circ: Genomic and Precision Medicine
    • → Circ: Cardiovascular Imaging
    • → Circ: Cardiovascular Interventions
    • → Circ: Cardiovascular Quality & Outcomes
    • → Circ: Heart Failure
    • Circulation Research
    • Hypertension
    • Stroke
    • Journal of the American Heart Association
  • Facebook
  • Twitter

  • My alerts
  • Sign In
  • Join

  • Advanced search

Header Publisher Menu

  • American Heart Association
  • Science Volunteer
  • Warning Signs
  • Advanced Search
  • Donate

Circulation

  • My alerts
  • Sign In
  • Join

  • Facebook
  • Twitter
  • Home
  • About this Journal
    • Editorial Board
    • General Statistics
    • Circulation Doodle
    • Information for Advertisers
    • Author Reprints
    • Commercial Reprints
    • Customer Service and Ordering Information
    • Subscribe to AHA Journals
  • All Issues
  • Subjects
    • All Subjects
    • Arrhythmia and Electrophysiology
    • Basic, Translational, and Clinical Research
    • Critical Care and Resuscitation
    • Epidemiology, Lifestyle, and Prevention
    • Genetics
    • Heart Failure and Cardiac Disease
    • Hypertension
    • Imaging and Diagnostic Testing
    • Intervention, Surgery, Transplantation
    • Quality and Outcomes
    • Stroke
    • Vascular Disease
  • Browse Features
    • AHA Guidelines and Statements
    • Bridging Disciplines
    • Circulation at Major Meetings
    • → Articles Bridging Discplines
    • Special Themed Issues
    • Global Impact of the 2017 ACC/AHA Hypertension Guidelines
    • Circulation Supplements
    • Cardiovascular Case Series
    • ECG Challenge
    • Hospitals of History
    • On My Mind
    • Podcast Archive
    • → Subscribe to Circulation on the Run
    • →Circulation FIT Podcast 2018
    • → #FITFAVs
  • Resources
    • Instructions for Authors
    • → Article Types
    • → General Preparation Instructions
    • → Research Guidelines
    • → How to Submit a Manuscript
    • Journal Policies
    • Permissions and Rights Q&A
    • Submission Sites
    • Circulation CME
    • AHA Journals RSS Feeds
    • International Users
    • AHA Newsroom
  • AHA Journals
    • AHA Journals Home
    • Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
    • Circulation
    • → Circ: Arrhythmia and Electrophysiology
    • → Circ: Genomic and Precision Medicine
    • → Circ: Cardiovascular Imaging
    • → Circ: Cardiovascular Interventions
    • → Circ: Cardiovascular Quality & Outcomes
    • → Circ: Heart Failure
    • Circulation Research
    • Hypertension
    • Stroke
    • Journal of the American Heart Association
Abstracts and presentations are embargoed for release at date and time of presentation or time of AHA/ASA news event. Failure to honor embargo policies (http://newsroom.heart.org/newsmedia/embargo-policy) will result in the abstract being withdrawn and barred from presentation.
Poster Abstract PresentationsSession Title: Nutrition 2

Abstract P273: Dietary Saturated Fatty Acids and Coronary Heart Disease Risk in a Dutch Elderly Population: Food Source and Carbon Chain Length Matter

Jaike Praagman, Ester A de Jonge, Jessica C Kiefte de Jong, Joline W Beulens, Ivonne Sluijs, Josje Schoufour, Albert Hofman, Yvonne T van der Schouw, Oscar H Franco
Circulation. 2016;133:AP273
Jaike Praagman
Julius Cntr, Univ Med Cntr Utrecht, Utrecht, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ester A de Jonge
Erasmus Med Cntr, Rotterdam, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jessica C Kiefte de Jong
Erasmus Med Cntr, Rotterdam, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joline W Beulens
VU Univ Med Cntr, Amsterdam, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ivonne Sluijs
Julius Cntr, Univ Med Cntr Utrecht, Utrecht, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Josje Schoufour
Erasmus Med Cntr, Rotterdam, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Albert Hofman
Erasmus Med Cntr, Rotterdam, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yvonne T van der Schouw
Julius Cntr, Univ Med Cntr Utrecht, Utrecht, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Oscar H Franco
Erasmus Med Cntr, Rotterdam, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics

Jump to

  • Article
  • Info & Metrics
  • eLetters
Loading

Abstract

Introduction: The association between dietary saturated fatty acids (SFA) and the risk of coronary heart disease (CHD) is heavily debated and appears to be more complex than initially thought. The food source and carbon chain length of SFA, as well as the macronutrient replacing SFA in the diet may affect the association between dietary SFA and CHD.

Hypothesis: We assessed the hypothesis that the association between dietary SFA and incident CHD is dependent on the food source of SFA, the carbon chain length of SFA, and the substituting macronutrient.

Methods: From the Rotterdam Study, we included 4,722 healthy men and women, aged 55 years or older. Baseline (1998-1993) SFA intake was assessed using a validated food frequency questionnaire. Incident CHD comprised fatal and non-fatal myocardial infarctions and coronary mortality up to January 2011, and was assessed through digital linkage with municipality records and general practitioners. We used multivariable Cox’ proportional hazard models to calculate CHD risks for higher intakes of total SFA, SFA from specific food sources, SFA differing in carbon chain length, and for higher intakes of other macronutrients at the expense of total SFA.

Results: During a median follow up of 16.3 years 569 CHD events occurred. Median total SFA intake was 15.7 en% per day, and the top three food sources were cheese (20.0%), meat (17.8%), and milk and milk products (13.1%). Total SFA intake was not significantly associated with CHD risk (Hazard Ratio (HR) per 5 en%: 1.13, 95%CI: 0.94, 1.22). Neither was SFA from specific food sources, although the data suggested an increased CHD risk for a higher intake of SFA from meat (HR per 1 en%: 1.06, 95%CI: 0.99, 1.14). Regarding SFA differing in carbon chain lengths, a higher CHD risk was observed for C16:0 intake (HR1en%: 1.18, 95%CI: 1.03, 1.35), but not for the remaining SFA. No significant associations with CHD risk were observed for each 5% lower intake of energy from SFA and a concomitant higher intake of 5% of energy from carbohydrates (HR5en%: 0.90: 0.80, 1.02), polyunsaturated fatty acids (HR5en%: 0.90, 95%CI: 0.71, 1.15), cis-monounsaturated fatty acids (HR5en%:1.09, 95%CI: 0.98, 1.22), or vegetable protein (HR5en%: 0.88, 95%CI: 0.50, 1.53).The exception was substitution of SFA with animal protein, which was associated with higher CHD risk (HR5en%: 1.24, 95%CI: 1.01, 1.51).

Conclusions: In this Dutch elderly population, with a high median intake of total SFA, the association between SFA intake and CHD risk depends on the SFA food source and carbon chain length. Future intervention studies are needed to determine the importance of the SFA food sources, and to confirm that C16:0 is more strongly related with CHD risk than other SFA.

  • Dietary fatty acids
  • Coronary heart disease
  • Epidemiology
  • Author Disclosures: J. Praagman: H. Other; Modest; Financially supported by a research Grant from Unilever R&D, Vlaardingen, the Netherlands. E.A.L. de Jonge: None. J.C. Kiefte de Jong: None. J.W.J. Beulens: None. I. Sluijs: None. J. Schoufour: None. A. Hofman: None. Y.T. van der Schouw: B. Research Grant; Modest; Research Grant from Unilever R&D, Vlaarderingen, the Netherlands. O.H. Franco: None.

  • © 2016 by American Heart Association, Inc.
Back to top
Previous Article

This Issue

Circulation
March 1, 2016, Volume 133, Issue Suppl 1
  • Table of Contents
Previous Article

Jump to

  • Article
  • Info & Metrics

Article Tools

  • Citation Tools
    Abstract P273: Dietary Saturated Fatty Acids and Coronary Heart Disease Risk in a Dutch Elderly Population: Food Source and Carbon Chain Length Matter
    Jaike Praagman, Ester A de Jonge, Jessica C Kiefte de Jong, Joline W Beulens, Ivonne Sluijs, Josje Schoufour, Albert Hofman, Yvonne T van der Schouw and Oscar H Franco
    Circulation. 2016;133:AP273, originally published March 1, 2016

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
  • Article Alerts
    Log in to Email Alerts with your email address.
  • Save to my folders

Share this Article

  • Email

    Thank you for your interest in spreading the word on Circulation.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Abstract P273: Dietary Saturated Fatty Acids and Coronary Heart Disease Risk in a Dutch Elderly Population: Food Source and Carbon Chain Length Matter
    (Your Name) has sent you a message from Circulation
    (Your Name) thought you would like to see the Circulation web site.
  • Share on Social Media
    Abstract P273: Dietary Saturated Fatty Acids and Coronary Heart Disease Risk in a Dutch Elderly Population: Food Source and Carbon Chain Length Matter
    Jaike Praagman, Ester A de Jonge, Jessica C Kiefte de Jong, Joline W Beulens, Ivonne Sluijs, Josje Schoufour, Albert Hofman, Yvonne T van der Schouw and Oscar H Franco
    Circulation. 2016;133:AP273, originally published March 1, 2016
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo

Related Articles

Cited By...

Circulation

  • About Circulation
  • Instructions for Authors
  • Circulation CME
  • Statements and Guidelines
  • Meeting Abstracts
  • Permissions
  • Journal Policies
  • Email Alerts
  • Open Access Information
  • AHA Journals RSS
  • AHA Newsroom

Editorial Office Address:
200 Fifth Avenue, Suite 1020
Waltham, MA 02451
email: circ@circulationjournal.org
 

Information for:
  • Advertisers
  • Subscribers
  • Subscriber Help
  • Institutions / Librarians
  • Institutional Subscriptions FAQ
  • International Users
American Heart Association Learn and Live
National Center
7272 Greenville Ave.
Dallas, TX 75231

Customer Service

  • 1-800-AHA-USA-1
  • 1-800-242-8721
  • Local Info
  • Contact Us

About Us

Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The need for our work is beyond question. Find Out More about the American Heart Association

  • Careers
  • SHOP
  • Latest Heart and Stroke News
  • AHA/ASA Media Newsroom

Our Sites

  • American Heart Association
  • American Stroke Association
  • For Professionals
  • More Sites

Take Action

  • Advocate
  • Donate
  • Planned Giving
  • Volunteer

Online Communities

  • AFib Support
  • Garden Community
  • Patient Support Network
  • Professional Online Network

Follow Us:

  • Follow Circulation on Twitter
  • Visit Circulation on Facebook
  • Follow Circulation on Google Plus
  • Follow Circulation on Instagram
  • Follow Circulation on Pinterest
  • Follow Circulation on YouTube
  • Rss Feeds
  • Privacy Policy
  • Copyright
  • Ethics Policy
  • Conflict of Interest Policy
  • Linking Policy
  • Diversity
  • Careers

©2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a qualified 501(c)(3) tax-exempt organization.
*Red Dress™ DHHS, Go Red™ AHA; National Wear Red Day ® is a registered trademark.

  • PUTTING PATIENTS FIRST National Health Council Standards of Excellence Certification Program
  • BBB Accredited Charity
  • Comodo Secured