Abstract P270: Higher Adherence to Mediterranean Diet is Associated with Lower Levels of D-Dimer: Findings From the MOLI-SANI Study
Introduction: Elevated D-dimer (D-d) levels are associated with higher cardiovascular (CVD) risk and total mortality. Variability of D-d levels in a healthy population is poorly explained by common CVD risk factors, and specific role of diet has not been investigated.
Hypothesis: We assessed the hypothesis that D-d levels are associated with adherence to Mediterranean Diet (MD).
Methods: We analyzed 17,403 (47% men, age≥35 yr, mean age 54±11 yr) apparently CVD or cancer[[Unable to Display Character: –]]free individuals randomly recruited from the general population of the MOLI-SANI study (Italy), for whom complete data on D-d, adherence to MD and C-Reactive Protein (CRP) were available. D-d was measured on fresh citrated plasma by an automated latex-enhanced immunoassay (HemosIL-IL, Milan). Food intake was recorded by the EPIC food frequency questionnaire. Adherence to the MD was appraised by the Greek Mediterranean diet score. D-d and CRP distributions were log transformed to reduce positive skewness.
Results: In multivariable analysis of variance adjusted for potential covariates (Table), high MD adherence was associated with lower D-d levels (Table). The difference in geometric means between individuals with the highest (175 ng/ml) versus the lowest (188 ng/ml) MD adherence was 13% of the standard deviation (SD) of D-d distribution in the whole population (SD=103 ng/ml). For comparison, the same difference was only 4% for CRP levels (SD=1.88 mg/dL). When log transformed distributions are considered, the previous differences (as percentages over SD) became 18% for D-d and 6% for CRP. These findings did not change when D-d was further adjusted for CRP or viceversa.
Conclusions: High adherence to MD is associated with lower D-d levels, in a large healthy adult population. The differences in D-d levels according to MD are much higher (in percentage to population variability) than those observed for CRP levels. These data suggest that high MD adherence is associated not only with a lower inflammatory status but also with a reduced tendency to develop thrombosis.
Author Disclosures: A. Di Castelnuovo: None. M. Bonaccio: None. A. De Curtis: None. S. Costanzo: None. M. Persichillo: None. G. de Gaetano: None. M. Donati: None. L. Iacoviello: None.
- © 2016 by American Heart Association, Inc.