Abstract P240: Neck Circumference is Associated with Carotid Intimal-media Thickness but Not with Coronary Artery Calcium: Results From the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Introduction: Previously, we identified that neck circumference can be a risk indicator for common carotid intima-media thickness among people with low cardiovascular risk factors among participants of the ELSA-Brasil. One potential explanation should be an effect of perivascular fat in the neck on common carotid intima-media thickness.
Hypothesis: we aim to compare the association of neck circumference with coronary artery calcium score and common carotid intima-media thickness in ELSA-Brasil. We hypothesized that a different pattern of association could reinforce the effect of local adiposity as a cause of atherosclerosis.
Methods: In cross-sectional and sex-specific analyses of 2,266 women (50.6 ±8.4 yrs) and 1,886 men (50.7 ±9.0 yrs) with both common carotid intima-media thickness and coronary artery calcium score free from previous coronary heart disease at baseline, we built logistic models using diverse cut-off points for coronary artery calcium score score (0 vs. >0, <100 vs ≥100, <400 vs ≥400 Agatston units) and common carotid intima-media thickness ( < 75th percentile vs ≥75 th ; < 90th percentile vs ≥90 th ) as dependent variables, after which adjustments for age and traditional cardiovascular risk factors were made.
Results: Mean (standard deviation) neck circumference was 33.6 (±2.4 cm) for women and 38.8 (±2.6 cm) for men. In fully adjusted models including sociodemographic, cardiovascular risk factors and body-mass index (BMI) and waist circumference, for each 1 standard deviation increase in neck circumference we found an odds ratio (OR, 95% CI) for having common carotid intima-media thickness above the 75th percentile of (1.52, 1.16; 1.99) for women and (1.66, 1.28; 2.14) for men, and above the 90th common carotid intima-media thickness percentile [1.66 (1.19; 2.32)for men but not for women [1.21 (0.80; 1.82)]. We found no association between neck circumference and coronary artery calcium score using several different cut-off points (p>0.05 for all).
Conclusion: Neck circumference was significantly and independently associated with common carotid intima-media thickness but not with coronary artery calcium score in women and men, indicating a possible effect of perivascular fat tissue on atherosclerosis
Author Disclosures: P.A. Lotufo: E. Honoraria; Modest; Abbott Brazil, Abbvie Brazil. C.M. Baena: None. A.C. Goulart: None. I.S. Santos: None. M.S. Bittencourt: None. B.B. Duncan: None. S. Liu: None. I.M. Bensenor: None.
- © 2016 by American Heart Association, Inc.