Abstract P196: Associations of Prenatal Antibiotics with Fetal Size and Cord Blood Leptin Levels: Findings From Project Viva
Background: Early postnatal antibiotic use appears to promote infant weight gain, but it is unclear how intrauterine exposure to antibiotics is associated with fetal growth and adiposity. The objective was to examine associations of antibiotic prescriptions in each trimester with fetal size and leptin levels at birth.
Methods: In 2128 pregnant women from the pre-birth Project Viva cohort, we estimated antibiotic prescribing by timing - any during pregnancy and trimester-specific - from electronic medical records. Outcomes were sex-specific birth weight-for-gestational-age z-scores (BW/GA-z) and cord blood leptin levels. We used linear regression models adjusted for maternal age, pre-pregnancy BMI, parity, race/ethnicity, education, smoking during pregnancy, household income and child sex and gestation length.
Results: 643 (30.2%) of women were prescribed antibiotics at any point during pregnancy. Mean (SD) BW/GA-z was 0.17 (0.97) and cord blood leptin was 9.0 ng/ml (6.6). In adjusted models, having an antibiotic prescription at any point during pregnancy was associated with lower BW/GA-z in (β -0.10; 95% CI -0.19, 0.00). In trimester-specific analyses, only 2nd trimester antibiotic prescriptions were associated with lower BW/GA-z (adj β -0.20; 95% CI -0.35, -0.06). Antibiotic prescription at any point in pregnancy was not associated with cord blood leptin. However, in trimester-specific analyses, 3rd trimester antibiotic prescriptions were associated with higher cord blood leptin (β 2.28 ng/ml; 95% CI 0.38, 4.17), while1st and 2nd trimester antibiotics were not associated with cord blood leptin.
Conclusion: Antibiotic prescriptions in mid-pregnancy were associated with lower BW/GA-z, whereas 3rd trimester prescriptions were associated with higher cord blood leptin.
Author Disclosures: N.T. Mueller: None. S.L. Rifas-Shiman: None. M.J. Blaser: None. M.W. Gillman: None. M. Hivert: None.
- © 2016 by American Heart Association, Inc.