Abstract P170: Lung Function Associated with Long-term Blood Pressure Variability in Young Adults: The Coronary Artery Risk Development in Young Adults Study
Introduction: Long-term blood pressure variability (BPV) has been shown to be associated with target-organ damage independent of mean BP. However, little is known about the factors that determine long-term BPV. Reduced lung function is associated with incidence of hypertension and may also predict long-term BPV.
Objective: To investigate the association between lung function and future long-term variability in systolic and diastolic BP among young adults.
Methods: We used data from Coronary Artery Risk Development in Young Adults Study among 3318 participants (mean age 26.4 years, 35% Males at baseline). Lung function was measured by forced vital capacity (FVC - the amount of air that can be maximally and forcibly expelled from the lungs after a maximal inhalation) at years 0, 2, 5, 10, and 20. BPV was measured using: i) average real variability (ARV) - mean of the absolute differences in BP between successive visits and ii) standard deviation (SD) of BP from years 0 to 25. In separate multiple linear regression models, ARV and SD of systolic and diastolic BP were regressed on quartiles and continuous variables of baseline FVC and FVC change from peak value to year 10 value.
Results: ARV and SD of systolic and diastolic BPs were significantly lower among participants with higher baseline FVC (quartiles 2, 3 and 4) as compared to those in quartile 1 after adjusting for mean BP and other confounders. Similarly, individuals who showed greater decline in FVC from peak to year 10 value (quartiles 3 and 4) showed significant higher ARV and SD of systolic and diastolic BPs as compared to those in quartile 1. Similar results were found when FVC was used as a continuous variable. There was significant trend in the association of long-term BPV with quartiles of baseline FVC and FVC change from peak to year 10 value (Table 1).
Conclusion: Among young adults, lower baseline FVC and higher decline in FVC over time was associated with higher long-term BPV independent of mean BP. Deterioration in lung function seems to be an independent risk factor for long-term BPV.
Author Disclosures: Y.G. Tedla: None. Y. Yano: None. B. Thyagarajan: None. R. Kalhan: None. R. Kumar: None. A. Viera: None. S. Rosenberg: None. P. Greenland: None. M. Carnethon: None.
- © 2016 by American Heart Association, Inc.