Abstract P106: Dense Low-density and Remnant Lipoprotein Cholesterol are Associated with Adiposity: The Elsa-Brasil Study
Introduction: Obesity is a known risk factor for coronary heart disease, and this relationship may be mediated by the presence of small dense low-density (LDL-3+LDL-4) and remnant (VLDL-3+IDL) lipoproteins. However, few studies with limited sample sizes have investigated the association of small dense low-density (SDLDL) and remnant lipoproteins (RL) with adiposity. One question is about these markers are only an epiphenomenon of high triglycerides or insulin resistance.
Hypothesis: to verify if these associations are mediated by levels of triglycerides and / or insulin resistance
Methods: We included 4,189 participants (50.6±8.6 years, 554% women, 58% White) from the ELSA-Brasil study who had no prior history of cardiovascular diseases were not currently using lipid-lowering medications, and had a BMI>18.5kg/m2. We measured the fasting lipoprotein cholesterol fractions using the vertical auto profile ultracentrifugation method. We investigated the association of BMI and WC with SDLDL and RL, using linear regression with a quadratic term for BMI and WC and adjusted for age, gender, HOMA-estimated insulin resistance, and fasting serum triglycerides.
Results: The mean LDL-3, LDL-4, VLDL-3, and IDL were respectively (mg/dL): 47.5±20.2, 10.5±10.8, 14.9±5.1, and 17.3±7.8. SDLDL had a quadratic association with BMI (linear:β=2.72, SE=0.53, p<0.0001; quadratic:β=-0.04, SE=0.01, p<0.0001), and WC (linear:β=1.94, SE=0.32, p<0.0001; quadratic:β=-0.01, SE=0.002, p<0.0001). RL showed also a quadratic association, mainly with WC (WC-linear:β=0.40, SE=0.13, p=0.002; quadratic:β=-0.002, SE=0.001, p=0.005; and BMI-linear:β=0.51, SE=0.21, p=0.01; quadratic:β=-0.01, SE=0.003, p=0.03).
Conclusion: In a large cohort of asymptomatic individuals, SDLDL and RL were both associated with measures of adiposity. These results occurred independently of plasma triglycerides and insulin resistance.
Author Disclosures: C. Suemoto: None. I.M. Bensenor: None. R. Santos: None. M.S. Bittencourt: None. S. Martin: None. P. Toth: None. S. Jones: None. M. Blaha: None. P.A. Lotufo: E. Honoraria; Modest; Abbot Brazil, Abbvie Brazil.
- © 2016 by American Heart Association, Inc.