Abstract P081: Late-onset Asthma Predicts Cardiovascular Disease Events: The Wisconsin Sleep Cohort
Background: Asthma is a heterogeneous syndrome with different clinical subtypes that is associated with an increased risk for cardiovascular disease (CVD). We hypothesized that the late-onset subtype of asthma is associated with a higher risk of incident CVD.
Methods: Presence of asthma and age of diagnosis were assessed at baseline in the ongoing population-based Wisconsin Sleep Cohort study, an investigation of sleep, respiratory and cardiovascular outcomes in adults followed prospectively since 1988. Late-onset asthma was defined as physician-diagnosed asthma at age 18 years or older. Participants were free of baseline CVD and followed for a mean (standard deviation) 13.9 (5.9) years for development of CVD (coronary death, myocardial infarction, angina, stroke, coronary revascularization, heart failure, or CVD death). Multivariable Cox regression models adjusted for age, sex, smoking, hypertension, body-mass index (BMI), and presence of diabetes mellitus were used to assess associations of late-onset asthma and incident CVD.
Results: The 1269 participants were 47.3 (8.0) years old; 166 participants had asthma (111 with late-onset asthma, 55 early-onset asthma and 1103 without asthma). Participants with late-onset asthma compared to non-asthmatics were more likely to be female (67% vs 44%), have a higher BMI (32.2 vs 29.4 kg/m2) and more likely to be hypertensive (38% vs 29%) (all p<0.05). Mean age of asthma diagnosis in the late-onset group was 39.5 (9.6) years vs. 8.9 (5.7) years in the early onset group (p< 0.0001). After adjustment for confounders, late-onset asthmatics had a higher risk of incident CVD events than non-asthmatics (Hazard Ratio 1.57, 95% confidence intervals 1.01-2.45, p=0.045, see figure). There was no interaction between BMI and age of asthma diagnosis on incident CVD (p=0.83).
Discussion: In a large cohort study of adults followed prospectively for over a decade, only late-onset asthmatics had an increased risk of incident CVD events. CVD risk associated with asthma may depend on asthma subtype.
Author Disclosures: M.C. Tattersall: None. J.H. Barnet: None. C.E. Korcarz: None. E.W. Hagen: None. P.E. Peppard: None. J.H. Stein: None.
- © 2016 by American Heart Association, Inc.