Abstract 20155: The Adverse Effect of End Stage Renal Disease on Intimal Hyperplasia of Internal Thoracic Artery
Introduction: Internal thoracic arteries (ITA) are widely used as a reliable conduit in coronary artery bypass grafting surgery (CABG) because they are said to be less affected by arterioscrelosis. Little is known about the relationships between patient’s characteristics and intimal hyperplasia of ITAs.
Hypothesis: The condition of intima of ITA of patients with end stage renal disease (ESRD) is worse than those of patients without ESRD.
Methods: The specimens of LITAs and RITAs, obtained from 48 patients who underwent CABG or OPCAB (off-pump CABG) , were evaluated with histopathology; 56 arteries were suitable for morphometric analysis. The severity of disease was evaluated on the basis of percentage of luminal narrowing (%LN) , intimal thickness index (ITI), and intima-to-media ratio (IMR).
Results: The patients included 36 males, 15 ESRD, 11 HD patients, 8 peripheral arterial disease (PAD) patients, and their average age was 69.3, average estimated glomerular filtration rate (eGFR) was 49.0 ml/min/1.73m2. The %LN was 6.26, ITI was 0.24, and IMR was 0.96 in average. In Spearman's rank correlation test, eGFR was associated with %LN (correlation coefficient -0.242, p=0.07). The %LN of patients with ESRD was significantly higher than that of patients without ESRD ( 7.99 vs 5.48, p=0.001).
Conclusions: The lumen of ITAs of patients with ESRD was significantly narrower than that of patients without ESRD.
Author Disclosures: H. Sato: None. Y. Ohashi: None. C. Ueki: None. T. Akimoto: None. G. Sakaguchi: None.
- © 2015 by American Heart Association, Inc.