Abstract 20097: Burden of Arrhythmias in Patients Hospitalized With Cardiac Amyloidosis
Introduction: Cardiac Amyloidosis (CA) predisposes patients to atrial and ventricular arrhythmias. Data on distribution of arrhythmias in this patient population is scarce. We sought to study the prevalence of various types of arrhythmias in this vulnerable patient population.
Methods: Patients hospitalized with a diagnosis of CA were identified using appropriate ICD 9 codes from the Nationwide Inpatient Sample for the period between 2007-2011. Cardiac arrhythmias listed in the discharge diagnosis were recorded based on ICD 9 codes. Statistical analysis was done using SAS v9.3 (Cary Institute Inc., Cary, NC).
Results: A total of 13,602 patients hospitalized for CA between 2007-2011 were identified of which 52.6% (n=7157) had an arrhythmia listed during the hospitalization (table). The most common arrhythmia was atrial fibrillation (AF) (32.3%, n= 4390), followed by ventricular tachycardia (9.9%, n=1352), atrial flutter (6.5%, n=878) and atrioventricular blocks (3.5%, n=470). There was no gender difference in prevalence of arrhythmias. All-cause mortality during hospitalization was 10%. In hospitalized patients, ventricular tachycardia was the most common life threatening arrhythmia followed by ventricular fibrillation.
Conclusions: CA patients have a high arrhythmia burden with a high incidence of AF and life threatening arrhythmias such as ventricular tachycardia and fibrillation. Whether this patient population will benefit from ICD implantation for primary prevention is not clearly known. Further research is required to identify specific arrhythmic risk factors and develop guidelines for primary prevention of sudden cardiac death in this patient population.
Author Disclosures: Y.M. Rochlani: None. S.N. Nishi: None. A. Hakeem: None. S. Bhatti: None.
- © 2015 by American Heart Association, Inc.