Abstract 19774: Weight Confirmed as a Risk Factor for Atrial Fibrillation in 39,023 Subjects
Introduction: Several risk factors for atrial fibrillation (AF) are long established including age, hypertension and left atrial volume (LAV). A more recently appreciated risk factor for AF is obesity.
Hypothesis: We hypothesize that increased weight associates independently with atrial fibrillation.
Methods: The database of all trans-thoracic echocardiograms (TTE) performed in a single cardiology department was interrogated for the five year period January 1, 2010 - December 31, 2014. Cardiac rhythm, age, sex, LAV, height, weight, systolic and diastolic BP data were extracted. Duplicate studies were removed. Data were analysed according to cardiac rhythm (AF vs sinus rhythm (SR)) by univariate comparisons (t tests) and multivariate linear regression.
Results: 39,023 studies were analysed [age 61±17 years, 52.8% male]. In 3,993 studies (10.2%) the cardiac rhythm was AF. The group with AF were older (74±11 vs 59±17 yrs, p<10-20), heavier (81.6±20.7 vs 78.6±20.0 kg, p<10-19), more likely male (58.9 vs 52.1%, p<10-15) and had larger LA volumes (71±33 vs 40±14 mL/m2, p<10-20) than those in SR. Height (166±11cm) was not different (p=0.69). A multivariate linear regression model was constructed incorporating age, LAV, weight, sex, diastolic and systolic BP (R2=0.28, p<10-20). In this model, weight was confirmed as an independent factor associated with AF (co-efficient 0.09, p<10-20).
Conclusions: Patients with AF were 3.0 kg heavier than those in SR. Weight remained independently associated with AF in the multivariate model. These retrospective observational data lend support to recent compelling data from a prospective randomised clinical trial showing that weight loss improved control of AF.
Author Disclosures: A.J. White: None. P. Mottram: None.
- © 2015 by American Heart Association, Inc.